Tuberculosis in Tropical Areas and Immigrants
Lorenzo Zammarchi1, Filippo Bartalesi2 and Alessandro Bartoloni1,2
Infectious Diseases Unit, Department of Experimental & Clinical
Medicine, University of Florence School of Medicine, Florence, Italy.
2 SOD Malattie Infettive e Tropicali, AOU Careggi, Firenze, Italy.
Received: April 11, 2014
Accepted: April 16, 2014
Meditterr J Hematol Infect Dis 2014, 6(1): e2014043, DOI 10.4084/MJHID.2014.043
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About 95% of cases and 98% of deaths due to tuberculosis (TB) occur in tropical countries while, in temperate low incidence countries, a disproportionate portion of TB cases is diagnosed in immigrants.
Urbanization, poverty, poor housing conditions and ventilation, poor nutritional status, low education level, the HIV co-epidemic, the growing impact of chronic conditions such as diabetes are the main determinants of the current TB epidemiology in tropical areas. TB care in these contests is complicated by several barriers such as geographical accessibility, educational, cultural, sociopsychological and gender issues. High quality microbiological and radiological facilities are not widely available, and erratic supply of anti-TB drugs may affect tropical areas from time to time. Nevertheless in recent years, TB control programs reached major achievements in tropical countries as demonstrated by several indicators.
Migrants have a high risk of acquire TB before migration. Moreover, after migration, they are exposed to additional risk factors for acquiring or reactivating TB infection, such as poverty, stressful living conditions, social inequalities, overcrowded housing, malnutrition, substance abuse, and limited access to health care. TB mass screening programs for migrants have been implemented in low endemic countries but present several limitations. Screening programs should not represent a stand-alone intervention, but a component of a wider approach integrated with other healthcare activities to ensure the health of migrants.
encouraging progress, the burden of tuberculosis (TB) remains enormous
with about one third of the World population latently infected with the
etiologic agent Mycobacterium
million new cases of active disease and 1.4 million people died in
2011. Some authors state that
95% of all cases and 98% of deaths due to TB, occurs in tropical
In the matter of facts among the 22 high burden countries that account
for more than 80% of the worldwide incident cases of the disease, 19
have territories geographically located, at least in part, within the
tropics (Table 1),
tropical areas as the most affected by TB in the World. In high income
industrialized countries, the majority of which are located outside the
tropics, the overall TB incidence is low, as expected given the inverse
correlation between economic development of the country and its TB
diffusion. A disproportionate
and growing portion
of subjects affected by TB in industrialized countries are migrants
from tropical countries,[5,6]
configuring this group of subjects as a TB vulnerable population in low
The aim of this review is to give an overview on the historical, epidemiological, clinical and microbiological characteristics and recent control strategies of TB in tropical countries and migrant populations.
|Table 1. High burden countries with territories located within the tropics and estimated incidence.|
History of TB in Tropical Areas and Migration
Current evidence supports the so called "Out-of-and-back-to-Africa"
scenario in explaining the origin and global spread of human TB. Human M. tuberculosis complex
probably originated in Africa and accompanied the Out-of-Africa
migrations of modern humans approximately 70,000 years ago. The three phylogenetically ‘modern’
lineages of M.
complex (namely the East Asian, the Central Asian/Delhi and the
Euro-American lineage) seeded in China, India and Europe, respectively
where human population strongly grew during the last few centuries.
As overcrowding conditions and the urbanization increased, TB expanded
in these areas and concomitantly spread globally through waves of human
migrations. Through European
colonization, the Euro-American lineage of M. tuberculosis
complex reached other regions such as the Americas in the mid
nineteenth century and sub-Saharan Africa at the beginning of the
twentieth century.[7,8] Historians
paleopathologists, supported by the detection of mycobacterial DNA in
pre-Columbian human remains, suggests that TB was already present in
pre-Columbian America. Today most TB in the Americas is caused by the
Euro-American lineage, but in the pre-Columbian period, the etiologic
agent may have been Asian forms, as would be expected given the
original human colonization of the Americas via the Bering Strait.
Alternatively, pre-Columbian TB might have been caused by mycobacterial
lineages which are now extinct perhaps because they were outcompeted by
the Euro-American lineage following the massive influx of Europeans
into the Americas between the early eighteenth and early twentieth
Epidemiology and Determinants of Tuberculosis in Tropical Areas
The majority of the known risk factors for acquiring TB infection and
for progress to TB disease after the infection are widespread and
responsible for the high burden of TB in tropical areas.
About 59% of new estimated TB cases occur in South East Asia and the Western Pacific Regions, where some of the most populated countries (India, China, Indonesia) and some of the most crowded cities of the World are located. Urbanization and the consequent overcrowded living conditions, through the increase of shared airspace between individuals, are among the well-known risk factors to acquire TB.
Urbanization is a relatively new, but growing phenomenon in Africa, which is substantially less populated than Asian regions. However, countries of the African Region account for 26% of the World's TB cases and they have the highest incidence rate of cases and death per capita. In Africa, the TB epidemic is overlapped and strongly driven by HIV infection which is the most powerful risk factor for developing active TB disease in subjects infected with M. tuberculosis. In this region, 46% of subjects who develop active TB are estimated to be co-infected with HIV (ranging from 8% in Ethiopia to 77% in Swaziland). In extreme settings, such as gold-mining workforce in South Africa, the annual incidence reaches value of 2,000-3,000 per 100,000 population due to the high rate of HIV co-infection (up to 80% among subjects with active TB) and silicosis.
Concerning countries of the region of Americas, only Brazil, is considered a high burden country given its relevant contribution to the absolute number of TB cases, despite a relatively low overall incidence rate (less than 50 per 100,000 population). However, the burden of TB in Brazil is not uniformly distributed in the national territories with more 70% of cases concentrated in 315 over 5,564 municípios corresponding to those hosting the large metropolitan cities where overcrowding and extreme poverty is more frequent. In some districts of São Paolo (Brazil) where the Human Development Index is particularly low, TB incidence is 167 per 100,000 population. Some tropical countries such as Haiti, Peru, Bolivia and Suriname have the highest incidence of TB in the Americas (between 100 and 200 per 100,000 population). HIV co-epidemic is probably one of the most important determinant of the high incidence found in Sub-Saharan Africa, as well in Brazil and Haiti, where about 20% of incident TB cases is HIV co-infected.
Re-infection of subjects with previous latent tuberculosis infection (LTBI), which account for up to 40% of the general population in countries like India, may play an important role. Even if people with LTBI, have a markedly lower risk of developing TB disease after a re-infection if compared with previously uninfected subjects, in endemic areas the contribution of re-infection may account up to 70% of TB relapse cases.
A very important, even if distal, determinant of TB in tropical areas is poverty that affects housing conditions, ventilation, nutritional status, education and the access to health care system. In some areas of India, for example, the amount of monthly earning as well as the schooling degree have been correlated to TB prevalence. About two third of cases are diagnosed between 15-44 years of age in countries such as South Africa and India. The impact on the health status of young adults in their most economically active years makes that not only does poverty predispose one to TB, but also TB can increase poverty. In India three to four months of work time, the equivalent to 20–30 per cent of annual household income, are typically lost because of TB.
A growing role of emergent risk factors for progression from latent to active TB, such as certain chronic conditions, have been observed more recently in tropical areas. Smoking doubles the risk of TB and might account for up to half of all deaths in men with TB in India. Diabetes is associated with an about three-times increase in TB risk accounting for about 20% of smear-positive tuberculosis cases in India in 2000. Helminthic infestations that are endemic in tropical countries are strongly suspected to negatively impact on TB diseases inducing immunological alterations including alternatively activation of macrophages and Th1-lymphocytes response impairment. In a cohort of HIV-infected Ugandan adults, Schistosoma mansoni infestation was associated with an increased risk of TB progression. Finally, according to a recent review of the literature on racial difference in susceptibility to infection by M. tuberculosis, black skin people may have consistently higher susceptibility to TB if compared to whites skin peoples due to environmental, immunologic, and genetic factors.
Epidemiology and Determinants of Tuberculosis in Immigrants
TB is a well-known phenomenon linked to migration. By the time of the
Italian migration to America between the XX and the XXI century,
Italian migrants, resettled in New York city, worked in the factories
of the metropolis in very poor housing and living conditions. In this
setting, Italian migrants experienced a very high number of TB cases
with tens of cases per household and the block where they lived was
named “lung’s block”.
Today, migration is a global social phenomenon that may be defined as a movement of people within and among countries as a consequence of wealth disparity, poverty, wars, natural disasters and political persecution.[19,25] To date there are an estimated 740 million internal migrants and 200 million of international migrants (Figure 1), without considering irregular migrants of which it is difficult to make an affordable estimate.
Many migrants originate from countries where TB have a high incidence, such as tropical countries, and resettle in higher income countries, such as Unites States, Canada, Australia, New Zealand and western Europe, where TB incidence is now very low (less than 10 per 100,000 population) (Table 2).
In the United States (US), TB cases in foreign-born persons accounted for 62% of total TB cases in 2011 with Asians accounting for 29% and Hispanics/Latinos for 21% of all cases. Considering the countries belonging to the European Economic Area (EEA), foreign origin persons represented 26% of cases diagnosed in 2011. However, this percentage rises to more than 40% in the western European countries holding the highest proportions of migrants in Europe (Table 2). In the EEA the majority of foreign origin subjects diagnosed with TB in 2009 originated from Asia (34.2%), Africa (28.6%) and other European countries (19.9%).
|Table 2. Number and portion of cases of active tuberculosis in foreign origin people diagnosed in countries of the European Economic Area and selected low TB incidence countries.[5,6,39,93,94]|
is playing an important role in the epidemiology of TB in certain high
burden countries with emerging economies. In some districts of São
Paolo (Brazil), the portion of TB cases diagnosed in Bolivian migrants
grew up to 53% of total cases in the period 1998-2008,
while migrant workers from rural areas of China resettled in the
district of Shanghai accounted for 67.4% of cases diagnosed in
It is clear that migrants currently play an important role in determining the current epidemiology of TB in countries where they settled. However reports from different high income countries with well-performing screening and treatment systems have shown that foreign-born TB patients do not contribute importantly to TB transmission in the native population.[25,29,30] Based on genotyping analysis, a variable portion of TB cases in native populations (ranging from 2% to 17%) has been attributed to transmission from foreign-born subjects.[31,32] In more recent study, performed in Denmark, transmission from Danes to migrants occurred 2.5 times more frequently than vice-versa.
Migrants are exposed in their country of origin to several risk factors for TB infection and progression as already explained in the above paragraph.
The incidence in the countries of origin is the strongest predictor of TB incidence in migrants according to some authors. However in other studies the TB incidence in selected migrant communities was found to be lower or higher if compared with the incidence in the country of origin according to the degree of socio-economical integration of the community.[34,35] After migration, foreign born people are exposed to a series of additional factors that have been associated with an increasing risk of acquiring or reactivating TB infection such as poverty, stressful living condition, material deprivation, social inequalities, unemployment, fewer educational opportunities, overcrowded housing, malnutrition, substance abuse, and limited access to health care.
TB in migrants may occur as a consequence of a reactivation of a LTBI acquired in the country of origin, but also because of a new infection acquired in the host country after resettlement or during travel in the country of origin. Molecular epidemiology studies have helped to understand the relevance of LTBI reactivation in the pathogenesis of TB in migrants. In these studies, clustered cases (defined as two or more cases with clonally related TB strains) are assumed to belong to a chain of recent transmission, while cases whose M. tuberculosis isolates display unique patterns are regarded as sporadic and assumed to be caused by reactivation. According to the different studies, 10%-45% of TB cases diagnosed in foreign-born patients are clustered,[35,37,38] this means that a relevant proportion of active TB cases is probably caused in immigrants by new infection acquired after migration, even if the majority of cases are due to LTBI reactivation acquired before migration.
As well known a considerable portion (23-53%) of TB cases in migrants is diagnosed in the first years (2-4) after resettlement in the host country.[6,39-41] However, the reasons for this phenomenon are not completely clear. Some authors suggest that the stressful and socioeconomically disadvantaged living conditions in the first years after migration could contribute to the reactivation of TB early after arrival.36 However, the risk of TB in migrants was found to persist for their life time. For example, in one study, one third of TB cases in Australia migrants were diagnosed 10 years after arrival, and this interval was larger when considering European migrants only.
An increased risk of TB is still present in second generation migrants in which a link to endemic countries persists after migration through social networks or travel in the country of origin of their ethnic minority group.[44,45] In United Kingdom (UK), for example, the highest incidence rates in UK born subjects are in ethnic minority groups. The role of travel to visit friends and relatives on the risk of TB infection during an international travel is not exactly known. However the risk for an international traveler approximates the risk of transmission in the local population of the country of destination, and it is associated with duration of travel. Among travelers, immigrant visiting friends and relatives, especially children, are likely to represent a group at higher risk, perhaps due to their closer contact with the local population as shown by several studies that report an association between TST positivity and return to the country of origin.
TB Diagnosis and Management in Tropical Areas
The most common symptom of pulmonary TB is a productive cough for more
than 2 weeks, which may be accompanied by other respiratory symptoms
(shortness of breath, chest pains, hemoptysis) and/or constitutional
symptoms (loss of appetite, weight loss, fever, night sweats, and
fatigue). The presence of
those symptoms are
enough to met the definition of suspected TB case according to the
World Health Organization (WHO).
For a patient living in a remote tropical village that has cough for more than 2 weeks, the way to achieve the correct diagnosis of TB, to start anti-tubercular treatment and to complete it successfully may be very long and full of hurdles. According to a systematic review, in resource limited countries the average patient delay (time from the onset of symptoms until the patient see the first health care practices) and average health system delay (time from the first health care seeking for diagnosis until the diagnosis made) are 31.7 days and 28.5 days, respectively.
Low educational level, low awareness and knowledge about TB and sociopsychological barriers, gender inequalities, are the first bottlenecks for the initial health access. Believing TB incurable or caused by evil spirit, possible social exclusion following the diagnosis of TB (stigma), fear of revealing HIV status to neighbors, since TB is closely related to HIV in tropical areas, are some the factors conditioning health seeking behaviors and the diagnostic delay in tropical countries.
Rural residence and other geographical barriers are further limiting factors in the diagnostic path. Ideally a health facility able to start the clinical management of a suspected TB case should be within 1-day walking distance as many patients have limited access to motorized vehicles. However, in 2011 the WHO estimates that only 15 of the 22 high TB burden countries met the target of having 1 microscopy centre per 100,000 population and 17 of the 36 countries with a high burden of TB and multidrug-resistant (MDR) TB have the recommended capacity of 1 laboratory to perform culture and drug susceptibility test (DST) per 5 million population.
Initial visit to a governmental low-level healthcare facility, initial visit to traditional or unqualified practitioner or even a visit to a private practitioner are factors associated with further diagnostic delay. The delay in diagnosis from this point forward reflects a lack of effective diagnostic tools and follow-up routines since a correct diagnosis requires both good training and available diagnostic facilities. Table 3 reports the list of the most important factors associated with diagnostic delay according to a systematic review.
|Table 3. Risk factors for TB diagnostic delay (adapted from Storla DG et al).|
of TB is a challenge not only in tropical countries, but anywhere
resources are limited. Conventional microbiological methodology such as
direct microscopy and culture, when available, have intrinsic
limitation that have constrained TB care and control up to now. Smear microscopy has a low
sensitivity (about 64%), which
is even lower in HIV positive patients
and in children.
Culture is considered the gold standard but requires some weeks to give
a positive result and even new liquid culture techniques, which are
more sensitive and allow a faster grown of mycobacteria, are seldom
available in resource-constrained settings largely because of cost.
Radiology has an important role in the diagnosis of TB but the
equipment is expensive to obtain, maintain, operate and experienced
radiologist are required in order to interpret the often non-specific
radiological signs of TB. Few
years ago, the
situation of radiological manpower and facilities in sub-Saharan Africa
was reported to show a desperate shortage of radiologists,
radiographers and equipment, with most of services located in the
capital with few at rural hospital and CT scanners or high resolution
ultrasound machines available only in 40% of these countries.
In view of the paucity of diagnostic tools available, the challenge of TB diagnosis in the tropics may be related to problems of differential diagnosis. In the tropics, pulmonary TB must be distinguished from other rare endemic and ubiquitous conditions such bacterial pneumonia, histoplasmosis, paracoccidioidomycosis, coccidioidomycosis, melioidosis, actinomycosis, paragonimiasis, echinococcosis, nocardial and aspergillus mycetoma, dirofilariosis, neoplasm, sarcoidosis,[58,59] which could be a hard task, given the limited diagnostic resources available.
Hopefully, the recent availability of new rapid tests could revolutionize TB care in endemic and tropical countries. The new test Xpert MTB/RIF, which has been endorsed by WHO in December 2010, is a cartridge-based automated diagnostic test that has three main advantages if compared with older tests: 1) it enables simultaneous detection of M. tuberculosis complex and rifampicin-resistant associated genotype; 2) provides accurate results in less than two hours so that patients can be offered proper treatment on the same day; 3) has minimal bio-safety requirements, training, and can be housed in non-conventional laboratories. According to a meta-analysis, the pooled sensitivity was 98.7% for pulmonary sputum positive TB and 75% for sputum negative TB with an overall specificity of 98.4%, while the sensitivity on non-respiratory clinical samples resulted to be 80.4%.[61,62] Xpert MTB/RIF showed dramatic cut of the time needed to start treatment, especially in smear negative cases, and to obtain rifampicin susceptibility result. With the introduction of Xpert MTB/RIF, there has been also an increase of the number of microbiologically confirmed TB in children, and an increase of the number of pulmonary TB cases detected in HIV positive patients when compared with microscopy. Between its endorsement by WHO and the end of June 2012, 1.1 million test cartridges were procured in 67 (46%) of the 145 countries eligible to purchase them at initial concessional prices (9.98 $ per test from August 2012). Currently, WHO strongly recommends the use of Xpert MTB/RIF for use, as the primary diagnostic test, in individuals suspected of having MDR or HIV-associated TB and in testing cerebrospinal fluid specimens from patients presumed to have TB meningitis; furthermore, WHO provides “conditional recommendations” for its use in other settings. However, several weakness of this new tool have already been highlighted, including elevated cost of the platform (17,000$), the sophisticated hardware needing calibration and maintenance, need of continuous electrical power supply and air conditioning, short shelf life of cartridges needing good procurement system, need for cartridges storage at 2-28°C and system for disposal after use. Concerning other relatively recent diagnostic tools such as interferon gamma release assays (IGRA) and serological test for TB, WHO recommended against their use in middle and low income countries for the diagnosis of both active and LTBI.
Directly Observed Treatment (DOT) of TB reduces TB related death, disability and transmission, and it is highly cost-effective intervention even in the lowest income countries. Treatment of a drug-sensitive TB, case, takes 6 months, while treatment for MDR TB case takes 18-20 months according to the WHO recommendations. The target of 85% of treatment success for new TB cases has been achieved at global level, but it is still under the goal threshold in African (73%), Americas (74%) and European Regions (74%), with the lowest rate (53%, possibly underestimated) reached by South Africa.
Concerning patients with MDR-TB, that represent a growing portion of cases, only 44% to 58% completed treatment successfully according to different Regions. In Africa, 19% of patients with MDR-TB is not able to complete the treatment because of death.
TB and HIV are strictly related, and the management of the two conditions must go hand in hand. To date only 40% of patients with TB are tested for HIV, with the African Region performing better than all other regions (69%). However only 56% of people eligible for antiretroviral therapy is receiving it in Africa. The assessment of the HIV status in a patient with TB is essential since the timely start of antiretroviral therapy has been demonstrated to reduce significantly the mortality of the patient.[66-68] Treatment success of TB is hampered by several problems that may be amplified especially in tropical areas, such as problematic access to health care facilities, poor adherence to treatment, availability of quality drugs, high rate of MDR cases, and HIV co-infection. Treatment default implies persistence of infection source, increased mortality, increased relapse rates and increased risk of the development of resistant strains.
In different case control studies, frequently identified risk factors associated with a default of the patients under TB treatment in tropical areas were inadequate knowledge on TB,[69,70] illiteracy or low education level,[70,71] herbal medication use, low income, alcohol abuse,[69-71] HIV co-infection,[69,71] male gender poor patient-provider interaction, side effects to anti TB drugs.
The erratic supply of drugs that may affect some areas is another relevant problem. A survey carried out in Ethiopia in 2008 showed that the first line drugs for TB treatment were not available in about 20% of 48 health facilities that were supposed to have. Doctors without Borders recently reported a drug supply crisis in Mthatha (South Africa) started in 2013. During a survey done in May 2013 in the area, still 40% of facilities suffered stock-outs of antiretroviral drugs and/or TB drugs with a median duration for reported stock-outs of 45 days.
TB Diagnosis and Management in Immigrants
The access to health system, including TB diagnostic and treatment
services is lower in migrant populations compared to native subjects.
Migrants have a longer patient diagnostic delay for TB (defined as the
time elapsed from the onset of symptoms and the first medical
consultation), while natives have a longer health care diagnostic delay
(defined as the time elapsed between the first medical consultation and
the initiation of treatment).[74,75]
patient delay is possibly due to a combination of reasons that hinder
migrants of using the available TB services. Among those factors, there
are language barriers, possible lack of medical insurance, fear of
deportation (for illegal migrants) or discontinuation of their
employment[74,75] and competing
priorities may prevail over health issues. Even if in most of countries
TB diagnosis and treatment are provided for free at government health
facilities to all migrants, including illegal migrants, additional
costs of transport and the time needed to perform medical consultations
may represent significant obstacles for access to health system for
migrants on low wages. The
longer health care
diagnostic delay in native subjects can be explained by the lower TB
incidence among native subjects in low endemic countries, that leads
physicians to reduce their index of suspicion regarding the possibility
of TB diagnosis and ordering other tests rather than TB-diagnostic
TB treatment in migrant populations can be challenging due to lower adherence to treatment.[77-79] According to a recent study, loss to follow-up in TB cases in UK appears to occur primarily in young male adults and in subjects born outside the UK, particularly those who migrated within the 2 years prior to diagnosis. Moreover, this study showed that lost to follow-up patients were more frequently infected with a resistant M. tuberculosis strain compared to patients who completed or were still on treatment (11% vs. 7.4%), highlighting the vicious circle among poor compliance to treatment and resistance to antitubercular drugs. Higher therapeutic abandonment has been recently found also in foreign born patients if compared to natives in Granada (Spain) and in Chinese internal migrants if compared to permanent residents.
Another challenging issue in the management of TB in migrants, in low endemic countries, is the high frequency of MDR-TB in this population if compared to natives (Table 4). The majority of European and other low prevalence countries, excluding some of the high priority countries in the WHO European Region (such as Latvia, Lithuania, Bulgaria and Estonia), report higher prevalence of MDR-TB cases in migrants if compared to the native population. This is probably due to the high prevalence of MDR-TB in migrants countries of origin and possibly to the low compliance to treatment that characterizes migrants and leads to acquire drug resistance.
|Table 4. Prevalence of Multi Drug Resistance in native and foreign origin subjects diagnosed with tuberculosis in countries of the European Economic Area and selected low TB incidence countries.[5,6,39,93,94]|
the epidemiological importance of migrant subjects in determining the
epidemiology of TB in industrialized countries, many of those countries
implemented different control measures for TB, including mass screening
programs. The rationale of these programs is the early detection and
treatment of active and then contagious TB cases, in order to prevent M. tuberculosis
transmission within the host country.
Indeed screening for active TB may decrease the period of
infectiousness by as much as 33%.
Secondary benefits of immigration screening are reduced transmission of
TB in the country of origin and during travel.
A recent survey showed that high-income industrialized countries have widely different approaches to the screening of migrants arriving in their territories. In the majority (23 of 25, 92%) of cases, screening is performed after the arrival, while only 36% (9 of 25) and 20% (5 of 25) of countries perform also pre-arrival and at-arrival screening respectively, according to the different type of immigrants. The majority of countries (25, 86.2%) screens for active TB and most commonly (76% of cases) the screening is compulsory. The most commonly used tool for screening for active TB in adult migrants is a chest radiograph, which is used by 22 of 25 (88%) industrialized countries alone or in combination with clinical examination and less commonly, with tuberculin skin test (TST). However, screening protocols based on chest x-ray only are unable to detect cases of extrapulmonary TB, which represent a not negligible portion of TB cases in migrant patients (24% of cases diagnosed in non US born patient in US). Moreover, concerning pulmonary TB, chest x-ray shows a sensitivity of 86-97% and a specificity of 75-89% according to the different criteria used for imaging interpretation. The median yield of screening for TB disease (portion of patients with active TB among those screened) has been found quite low (0.18%) in the EEA.
Only 16 of 29 (55.2%) \countries, inquired in the above survey, screens for LTBI by using TST in 68.8% of cases or TST plus a confirmatory IGRA in 25% or an IGRA alone in 18.8%. Some authors strongly support the implementation of screening for LTBI based on the evidence that the majority of active TB cases, diagnosed in migrants, are due to a LTBI reactivation acquired in the country of origin and on the findings of cost-effectiveness analysis.[87,88] According to a cost-effectiveness study, the most suitable strategy would be to screen with an IGRA (in particular QuantiFERON-TB Gold In-Tube. Carnegie, Cellestis, Australia) test all migrants coming in UK from countries with an incidence of more than 250 cases per 100,000 (incremental cost-effectiveness ratio [ICER] of £ 21,565 per prevented case of TB) without port of arrival chest x-ray. However these results are opposite to those of a previous study done in Canada that found chest radiograph the most and Quantiferon the least cost-effective strategy to screen migrants. The discordance of the findings are probably explained by the different assumptions done in the models such as high rates of acceptance and completion of chemoprophylaxis assumed in the English study and low prevalence of latent infection in new immigrants assumed in the Canadian study.
While the attention of the different governmental programs and several scientists seems to focus on mass screening programs for active TB and/or LTBI, this kind of interventions should not represent a stand-alone intervention, but a component of a wider approach. The six points proposed by the STOP TB strategy (Table 5), which address the activities to deal with TB at global level, could be a useful paradigm for drawing a more comprehensive approach for TB control in migrant populations.
Implementing DOT in low endemic areas or newer socially and culturally acceptable programs to sustain treatment adherence, address MDR-TB, contributing to health systems strengthening with the presence of peer educators and culturally-oriented health staff, engaging all care providers including members of Non Governmental Organizations and voluntary associations, empowering migrants communities and promoting research to find new possible operational solutions and tools for TB care and prevention could likely be of benefit for future TB control programs in migrants.
In conclusion TB care should be offered and integrated with other healthcare activities within the context of a holistic approach to ensure the health and wellbeing of new entrant migrants.[76,91,92]
|Table 5. The six components of the STOP TB strategy.|
- C. Dye, S. Scheele, P. Dolin, V. Pathania,
M.C. Raviglione, Consensus statement. Global burden of tuberculosis:
estimated incidence, prevalence, and mortality by country. WHO Global
Surveillance and Monitoring Project, JAMA: the journal of the American
Medical Association, 282 (1999) 677-686. http://dx.doi.org/10.1001/jama.282.7.677 PMid:10517722
- World Health Organization, Global Tuberculosis Report 2012, (2012).
- J.M. Grange, A.I. Zumla, Tuberculosis, in: G.C. Cook, I.Z. Alimuddin (Eds.) Manson's Tropical Diseases, Saunders Elsevier, 2009, pp. 983-1038.
- G.B. Ploubidis, M.J. Palmer, C. Blackmore, T.A. Lim, D. Manissero, A. Sandgren, J.C. Semenza, Social determinants of tuberculosis in Europe: a prospective ecological study, The European respiratory journal, 40 (2012) 925-930. http://dx.doi.org/10.1183/09031936.00184011 PMid:22267772
- European Centre for Disease Control and Prevention, Tuberculosis surveillance and monitoring in Europe 2013, (2013).
- CDC, Reported Tuberculosis in the United States, 2011, Department of Health and Human Services, (October 2012).
- S. Gagneux, Host-pathogen coevolution in human tuberculosis, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 367 (2012) 850-859. http://dx.doi.org/10.1098/rstb.2011.0316 PMid:22312052 PMCid:PMC3267123
- W. Stead, The origin and erratic global spread of tuberculosis. How the past explains the present and is the key to the future, Clin Chest Med, 18 (1997) 65-77. http://dx.doi.org/10.1016/S0272-5231(05)70356-7
- E. Alirol, L. Getaz, B. Stoll, F. Chappuis, L. Loutan, Urbanisation and infectious diseases in a globalised world, The Lancet infectious diseases, 11 (2011) 131-141. http://dx.doi.org/10.1016/S1473-3099(10)70223-1
- E. Vynnycky, P.E. Fine, Interpreting the decline in tuberculosis: the role of secular trends in effective contact, International journal of epidemiology, 28 (1999) 327-334. http://dx.doi.org/10.1093/ije/28.2.327 PMid:10342699
- D. Cohn, W. El Sadr, Treatment of latent
tuberculosis infection., in: L. Reichman, E. Hershfield (Eds.)
Tuberculosis: a comprehensive international approach., Marcel Dekker,
New York, 2000.
- C.L. van Halsema, K.L. Fielding, V.N. Chihota, J.J. Lewis, G.J. Churchyard, A.D. Grant, Trends in drug-resistant tuberculosis in a gold-mining workforce in South Africa, 2002-2008, The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 16 (2012) 967-973.
- M. Hijjar, M. Procopia, Tubercolose Epidemiologia e Controle No Brasil, Revista do Hospital Universitário Pedro Ernesto, Ano 5 Julho/ Dezembro (2006).
- V.N. Martinez, N.K. Komatsu, S.M. De Figueredo, E.A. Waldman, Equity in health: tuberculosis in the Bolivian immigrant community of Sao Paulo, Brazil, Tropical medicine & international health: TM & IH, (2012).
- Pan American Health Organization, Regional
office of the World Health Organization, Tuberculosis in the Region of
the Americas, Regional Report 2011. Epidemiology, Control and
- Government of India. Central TB Division., TB India 2011. Revised National TB Control Programme. Annual Status Report, (2011).
- J.R. Andrews, F. Noubary, R.P. Walensky, R. Cerda, E. Losina, C.R. Horsburgh, Risk of progression to active tuberculosis following reinfection with Mycobacterium tuberculosis, Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 54 (2012) 784-791.
- A. van Rie, R. Warren, M. Richardson, T.C. Victor, R.P. Gie, D.A. Enarson, N. Beyers, P.D. van Helden, Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment, The New England journal of medicine, 341 (1999) 1174-1179. http://dx.doi.org/10.1056/NEJM199910143411602 PMid:10519895
- A human rights approach to TB. Stop TB
Guidelines for Social Mobilization. THE STOP TB PARTNERSHIP SECRETARIAT
is hosted by the World Health Organization, in, 2001.
- S.D. Lawn, A.I. Zumla, Tuberculosis, Lancet, 378 (2011) 57-72. http://dx.doi.org/10.1016/S0140-6736(10)62173-3
- W. Rafi, R. Ribeiro-Rodrigues, J.J. Ellner, P. Salgame, 'Coinfection-helminthes and tuberculosis', Current opinion in HIV and AIDS, 7 (2012) 239-244.
- M. Brown, G. Miiro, P. Nkurunziza, C. Watera, M.A. Quigley, D.W. Dunne, J.A. Whitworth, A.M. Elliott, Schistosoma mansoni, nematode infections, and progression to active tuberculosis among HIV-1-infected Ugandans, The American journal of tropical medicine and hygiene, 74 (2006) 819-825. PMid:16687687
- A. Fares, Racial differences in susceptibility to infection by Mycobacterium tuberculosis, Ann Trop Med Public Health 5(2012) 307-312. http://dx.doi.org/10.4103/1755-6783.102032
- L. Sestini, Profilassi della Emigrazione e Polizia Sanitaria Marittima, Unione tipografico-editrice torinese, (1928).
- D. Falzon, M. Zignol, G.B. Migliori, P. Nunn, M.C. Raviglione, Migration: an opportunity for the improved management of tuberculosis worldwide, Italian Journal of Public Health, 9 (2012) e75241-752411.
- UNDP, Summary. Human Development Report
2009. Overcoming barriers: Human mobility and development, United
Nations Development Program, (2009).
- European Centre for Disease Control and
Prevention, WHO Regional Office for Europe, Tuberculosis surveillance
in Europe 2009., Stockholm, European Centre for Disease Control and
- X. Shen, Z. Xia, X. Li, J. Wu, L. Wang, J. Li, Y. Jiang, J. Guo, J. Chen, J. Hong, Z. Yuan, Q. Pan, K. DeRiemer, G. Sun, Q. Gao, J. Mei, Tuberculosis in an urban area in China: differences between urban migrants and local residents, PloS one, 7 (2012) e51133. http://dx.doi.org/10.1371/journal.pone.0051133 PMid:23226479 PMCid:PMC3511410
- J. Barniol, S. Niemann, V.R. Louis, B. Brodhun, C. Dreweck, E. Richter, H. Becher, W. Haas, T. Junghanss, Transmission dynamics of pulmonary tuberculosis between autochthonous and immigrant sub-populations, BMC infectious diseases, 9 (2009) 197. http://dx.doi.org/10.1186/1471-2334-9-197 PMid:19961606 PMCid:PMC3224697
- Z. Kamper-Jorgensen, A.B. Andersen, A. Kok-Jensen, M. Kamper-Jorgensen, I.C. Bygbjerg, P.H. Andersen, V.O. Thomsen, T. Lillebaek, Migrant tuberculosis: the extent of transmission in a low burden country, BMC infectious diseases, 12 (2012) 60. http://dx.doi.org/10.1186/1471-2334-12-60 PMid:22423983 PMCid:PMC3342118
- D.P. Chin, K. DeRiemer, P.M. Small, A.P. de Leon, R. Steinhart, G.F. Schecter, C.L. Daley, A.R. Moss, E.A. Paz, R.M. Jasmer, C.B. Agasino, P.C. Hopewell, Differences in contributing factors to tuberculosis incidence in U.S. -born and foreign-born persons, American journal of respiratory and critical care medicine, 158 (1998) 1797-1803. http://dx.doi.org/10.1164/ajrccm.158.6.9804029 PMid:9847270
- M.W. Borgdorff, N. Nagelkerke, D. van Soolingen, P.E. de Haas, J. Veen, J.D. van Embden, Analysis of tuberculosis transmission between nationalities in the Netherlands in the period 1993-1995 using DNA fingerprinting, American journal of epidemiology, 147 (1998) 187-195. http://dx.doi.org/10.1093/oxfordjournals.aje.a009433 PMid:9457010
- R.E. Watkins, A.J. Plant, Predicting tuberculosis among migrant groups, Epidemiology and infection, 129 (2002) 623-628. http://dx.doi.org/10.1017/S0950268802007604 PMid:12558347 PMCid:PMC2869926
- L.R. Codecasa, A.D. Porretta, A. Gori, F. Franzetti, A. Degli Esposti, A. Lizioli, V. Carreri, M.C. Di Proietto, F. Perozziello, G. Besozzi, Tuberculosis among immigrants from developing countries in the province of Milan, 1993-1996, The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 3 (1999) 589-595.
- F. Franzetti, L. Codecasa, A. Matteelli, A. Degli Esposti, A. Bandera, C. Lacchini, A. Lombardi, G. Pinsi, F. Zanini, I. El-Hamad, A. Gori, Genotyping analyses of tuberculosis transmission among immigrant residents in Italy, Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 16 (2010) 1149-1154.
- S. Reitmanova, D. Gustafson, Rethinking immigrant tuberculosis control in Canada: from medical surveillance to tackling social determinants of health, Journal of immigrant and minority health / Center for Minority Public Health, 14 (2012) 6-13.
- E. Hernandez-Garduno, D. Kunimoto, L. Wang, M. Rodrigues, R.K. Elwood, W. Black, S. Mak, J.M. FitzGerald, Predictors of clustering of tuberculosis in Greater Vancouver: a molecular epidemiologic study, CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne, 167 (2002) 349-352.
- A. Fok, Y. Numata, M. Schulzer, M.J. FitzGerald, Risk factors for clustering of tuberculosis cases: a systematic review of population-based molecular epidemiology studies, The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 12 (2008) 480-492.
- C. Barry, J. Waring, R. Stapledon, A. Konstantinos, and the National Tuberculosis Advisory Committee for the Communicable Diseases Network Australia, Tuberculosis Notifications in Australia 2008 and 2009, Communicable Diseases Intelligence, 36 (2012) 82-94.
- Health Protection Agency, Tuberculosis in
the UK: Annual report on tuberculosis surveillance in the UK, 2012,
London, (July 2012).
- M. Morandi, D. Resi, F. Morsillo, M.L.
Moro, S. D'Amato, E. Rizzuto, M.G. Pompa, L. Fattorini, B. Suligoi,
Rapporto: la tubercolosi in Italia. Anno 2008., Agenzia Sanitaria e
Sociale Regione Emilia-Romagna, Ministero della Salute, Istituto
Superiore di Sanità., (2008).
- A.E. McCarthy, L.H. Weld, E.D. Barnett, H. So, C. Coyle, C. Greenaway, W. Stauffer, K. Leder, R. Lopez-Velez, P. Gautret, F. Castelli, N. Jenks, P.F. Walker, L. Loutan, M. Cetron, Spectrum of illness in international migrants seen at GeoSentinel clinics in 1997-2009, part 2: migrants resettled internationally and evaluated for specific health concerns, Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 56 (2013) 925-933.
- M.E. McPherson, H. Kelly, M.S. Patel, D. Leslie, Persistent risk of tuberculosis in migrants a decade after arrival in Australia, The Medical journal of Australia, 188 (2008) 528-531. PMid:18459925
- Public Health England, Tuberculosis, Key messages for primary care pratictioners, On line, (Consulted on 26/07/2013).
- Health Protection Agency Centre for
Infections, Tuberculosis in the UK: Annual report on tuberculosis
surveillance in the UK, 2010., London, (October 2010).
- Health Protection Services, Migrant
Health: Infectious diseases in non-UK born populations in the UK. An
update to the baseline report - 2011, London: Health Protection
- F.G. Cobelens, H. van Deutekom, I.W. Draayer-Jansen, A.C. Schepp-Beelen, P.J. van Gerven, R.P. van Kessel, M.E. Mensen, Risk of infection with Mycobacterium tuberculosis in travellers to areas of high tuberculosis endemicity, Lancet, 356 (2000) 461-465. http://dx.doi.org/10.1016/S0140-6736(00)02554-X
- F.G. Cobelens, H. van Deutekom, I.W. Draayer-Jansen, A.C. Schepp-Beelen, P.J. van Gerven, R.P. van Kessel, M.E. Mensen, Association of tuberculin sensitivity in Dutch adults with history of travel to areas of with a high incidence of tuberculosis, Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 33 (2001) 300-304.
- Public Health Agency of Canada, Risk
assessment and prevention of tuberculosis among travellers, Canada
Communicable Disease Report, 35 (2009).
- World Health Organization, Treatment of tuberculosis guidelines. Fourth edition., (2010).
- C.T. Sreeramareddy, K.V. Panduru, J. Menten, J. Van den Ende, Time delays in diagnosis of pulmonary tuberculosis: a systematic review of literature, BMC infectious diseases, 9 (2009) 91. http://dx.doi.org/10.1186/1471-2334-9-91 PMid:19519917 PMCid:PMC2702369
- D.G. Storla, S. Yimer, G.A. Bjune, A systematic review of delay in the diagnosis and treatment of tuberculosis, BMC public health, 8 (2008) 15. http://dx.doi.org/10.1186/1471-2458-8-15 PMid:18194573 PMCid:PMC2265684
- J.L. Davis, A. Cattamanchi, L.E. Cuevas, P.C. Hopewell, K.R. Steingart, Diagnostic accuracy of same-day microscopy versus standard microscopy for pulmonary tuberculosis: a systematic review and meta-analysis, The Lancet infectious diseases, 13 (2013) 147-154. http://dx.doi.org/10.1016/S1473-3099(12)70232-3
- L. Chaidir, I. Parwati, J. Annisa, S. Muhsinin, I. Meilana, B. Alisjahbana, R. van Crevel, Implementation of LED fluorescence microscopy for diagnosis of pulmonary and HIV-associated tuberculosis in a hospital setting in Indonesia, PloS one, 8 (2013) e61727.
- H.J. Zar, L. Workman, W. Isaacs, K. Dheda, W. Zemanay, M.P. Nicol, Rapid diagnosis of pulmonary tuberculosis in African children in a primary care setting by use of Xpert MTB/RIF on respiratory specimens: a prospective study, The Lancet, 1 (2013) e97-e104.
- V.N. Chihota, A.D. Grant, K. Fielding, B. Ndibongo, A. van Zyl, D. Muirhead, G.J. Churchyard, Liquid vs. solid culture for tuberculosis: performance and cost in a resource-constrained setting, The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 14 (2010) 1024-1031.
- E.T. Tshibwabwa, M.G. Kawooya, Z. Muyinda,
Trends in radiology and imaging sercices in the tropics, in: G.C. Cook,
A. Zumla (Eds.) Manson's Tropical Diseases, Saunders Elsevier, 2009,
- S.M. Graham, S.B. Gordon, Respiratory
problems in the tropics, in: G.C. Cook, A. Zumla (Eds.) Manson's
Tropical Diseases, Saunders Elsevier, 2009, pp. 143-150.
- T.J.J. Inglis, Respiratory Tract
Infections in the Tropics, in: J.M. Goldsmid, P.A. Leggat (Eds.) Primer
of Tropical Medicine, The Australasian College of Tropical Medicine
- World Health Organization, Tuberculosis diagnostics: automated DNA test., Geneva, Switzerland, (2010).
- K. Chang, W. Lu, J. Wang, K. Zhang, S. Jia, F. Li, S. Deng, M. Chen, Rapid and effective diagnosis of tuberculosis and rifampicin resistance with Xpert MTB/RIF assay: a meta-analysis, The Journal of infection, 64 (2012) 580-588. http://dx.doi.org/10.1016/j.jinf.2012.02.012 PMid:22381459
- S.D. Lawn, P. Mwaba, M. Bates, A. Piatek, H. Alexander, B.J. Marais, L.E. Cuevas, T.D. McHugh, L. Zijenah, N. Kapata, I. Abubakar, R. McNerney, M. Hoelscher, Z.A. Memish, G.B. Migliori, P. Kim, M. Maeurer, M. Schito, A. Zumla, Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test, The Lancet infectious diseases, 13 (2013) 349-361. http://dx.doi.org/10.1016/S1473-3099(13)70008-2
- C.C. Boehme, M.P. Nicol, P. Nabeta, J.S. Michael, E. Gotuzzo, R. Tahirli, M.T. Gler, R. Blakemore, W. Worodria, C. Gray, L. Huang, T. Caceres, R. Mehdiyev, L. Raymond, A. Whitelaw, K. Sagadevan, H. Alexander, H. Albert, F. Cobelens, H. Cox, D. Alland, M.D. Perkins, Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study, Lancet, 377 (2011) 1495-1505. http://dx.doi.org/10.1016/S0140-6736(11)60438-8
- World Health Organization, Tuberculosis Diagnostic Xpert MTB/RIF Test. Updated WHO recommendations as of October 2013, (2013).
- UNAIDS, UNAIDS World AIDS Day Report 2012, (2012).
- F.X. Blanc, T. Sok, D. Laureillard, L. Borand, C. Rekacewicz, E. Nerrienet, Y. Madec, O. Marcy, S. Chan, N. Prak, C. Kim, K.K. Lak, C. Hak, B. Dim, C.I. Sin, S. Sun, B. Guillard, B. Sar, S. Vong, M. Fernandez, L. Fox, J.F. Delfraissy, A.E. Goldfeld, Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis, The New England journal of medicine, 365 (2011) 1471-1481. http://dx.doi.org/10.1056/NEJMoa1013911 PMid:22010913
- D.V. Havlir, M.A. Kendall, P. Ive, J. Kumwenda, S. Swindells, S.S. Qasba, A.F. Luetkemeyer, E. Hogg, J.F. Rooney, X. Wu, M.C. Hosseinipour, U. Lalloo, V.G. Veloso, F.F. Some, N. Kumarasamy, N. Padayatchi, B.R. Santos, S. Reid, J. Hakim, L. Mohapi, P. Mugyenyi, J. Sanchez, J.R. Lama, J.W. Pape, A. Sanchez, A. Asmelash, E. Moko, F. Sawe, J. Andersen, I. Sanne, Timing of antiretroviral therapy for HIV-1 infection and tuberculosis, The New England journal of medicine, 365 (2011) 1482-1491. http://dx.doi.org/10.1056/NEJMoa1013607 PMid:22010914 PMCid:PMC3327101
- S.S. Abdool Karim, K. Naidoo, A. Grobler, N. Padayatchi, C. Baxter, A.L. Gray, T. Gengiah, S. Gengiah, A. Naidoo, N. Jithoo, G. Nair, W.M. El-Sadr, G. Friedland, Q. Abdool Karim, Integration of antiretroviral therapy with tuberculosis treatment, The New England journal of medicine, 365 (2011) 1492-1501. http://dx.doi.org/10.1056/NEJMoa1014181 PMid:22010915 PMCid:PMC3233684
- B.N. Muture, M.N. Keraka, P.K. Kimuu, E.W. Kabiru, V.O. Ombeka, F. Oguya, Factors associated with default from treatment among tuberculosis patients in Nairobi province, Kenya: a case control study, BMC public health, 11 (2011) 696. http://dx.doi.org/10.1186/1471-2458-11-696 PMid:21906291 PMCid:PMC3224095
- S. Vijay, P. Kumar, L.S. Chauhan, B.H. Vollepore, U.P. Kizhakkethil, S.G. Rao, Risk factors associated with default among new smear positive TB patients treated under DOTS in India, PloS one, 5 (2010) e10043. http://dx.doi.org/10.1371/journal.pone.0010043 PMid:20386611 PMCid:PMC2850369
- S. Garrido Mda, M.L. Penna, T.M. Perez-Porcuna, A.B. de Souza, S. Marreiro Lda, B.C. Albuquerque, F.E. Martinez-Espinosa, S. Buhrer-Sekula, Factors associated with tuberculosis treatment default in an endemic area of the Brazilian Amazon: a case control-study, PloS one, 7 (2012) e39134. http://dx.doi.org/10.1371/journal.pone.0039134 PMid:22720052 PMCid:PMC3373579
- G. Daniel, H. Tegegnework, T. Demissie, R. Reithinger, Pilot assessment of supply chains for pharmaceuticals and medical commodities for malaria, tuberculosis and HIV infection in Ethiopia, Transactions of the Royal Society of Tropical Medicine and Hygiene, 106 (2012) 60-62. http://dx.doi.org/10.1016/j.trstmh.2011.09.008 PMid:22093812
- Doctors without Borders, the Rural Health Advocacy Project (RHAP), Treatment Action Campaign (TAC), and SECTION27, Report. The Chronic Crisis: Essential drug stock-outs risk unnecessary death and drug resistance in South Africa, (2013).
- Z. Mor, H. Kolb, M. Lidji, G. Migliori, A. Leventhal, Tuberculosis diagnostic delay and therapy outcomes of non-national migrants in Tel Aviv, 1998-2008, Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 18 (2013).
- C. Gagliotti, D. Resi, M.L. Moro, Delay in the treatment of pulmonary TB in a changing demographic scenario, The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 10 (2006) 305-309.
- E. Pontali, G. Sotgiu, Chapter 14. TB in migrants, Eur Respir Monogr, 58 (2012) 194-205.
- E.R. Millett, D. Noel, P. Mangtani, I. Abubakar, M.E. Kruijshaar, Factors associated with being lost to follow-up before completing tuberculosis treatment: analysis of surveillance data, Epidemiology and infection, 141 (2013) 1223-1231. http://dx.doi.org/10.1017/S095026881200163X PMid:22846385
- C. Zhou, J. Chu, J. Liu, R. Gai Tobe, H. Gen, X. Wang, W. Zheng, L. Xu, Adherence to tuberculosis treatment among migrant pulmonary tuberculosis patients in Shandong, China: a quantitative survey study, PloS one, 7 (2012) e52334. http://dx.doi.org/10.1371/journal.pone.0052334 PMid:23284993 PMCid:PMC3524106
- M.J. Molina Rueda, A. Fernandez Ajuria, M.M. Rodriguez Del Aguila, B. Lopez Hernandez, [Factors associated to dropout of tuberculostatic treatment in the province of Granada], Revista clinica espanola, 212 (2012) 383-388. http://dx.doi.org/10.1016/j.rce.2012.03.013 PMid:22608191
- World Health Organization, Plan to Stop TB in 18 High-priority Countries in the WHO European Region, 2007–2015 (2007).
- G.G. Alvarez, B. Gushulak, K. Abu Rumman, E. Altpeter, D. Chemtob, P. Douglas, C. Erkens, P. Helbling, I. Hamilton, J. Jones, A. Matteelli, M.C. Paty, D.L. Posey, D. Sagebiel, E. Slump, A. Tegnell, E.R. Valin, B.A. Winje, E. Ellis, A comparative examination of tuberculosis immigration medical screening programs from selected countries with high immigration and low tuberculosis incidence rates, BMC infectious diseases, 11 (2011) 3. http://dx.doi.org/10.1186/1471-2334-11-3 PMid:21205318 PMCid:PMC3022715
- S. Verver, R. Bwire, M.W. Borgdorff, Screening for pulmonary tuberculosis among immigrants: estimated effect on severity of disease and duration of infectiousness, The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 5 (2001) 419-425.
- M. Pareek, I. Baussano, I. Abubakar, C. Dye, A. Lalvani, Evaluation of immigrant tuberculosis screening in industrialized countries, Emerging infectious diseases, 18 (2012) 1422-1429. http://dx.doi.org/10.3201/eid1809.120128 PMid:22931959 PMCid:PMC3437731
- H.M. Peto, R.H. Pratt, T.A. Harrington, P.A. LoBue, L.R. Armstrong, Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006, Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 49 (2009) 1350-1357.
- A. van't Hoog, M. Langendam, Mitchell, F. Cobelens, D. Sinclair, M. Leeflang, K. Lonnroth, A systematic review of the sensitivity and specificity of symptom- and chest-radiography screening for active pulmonary tuberculosis in HIV-negative persons and persons with unknown HIV status.REPORT - Version March 2013, Downloaded from http://www.who.int/tb/tbscreening/en/ on 25 August 2013, (2013).
- E. Klinkenberg, D. Manissero, J.C. Semenza, S. Verver, Migrant tuberculosis screening in the EU/EEA: yield, coverage and limitations, The European respiratory journal, 34 (2009) 1180-1189. http://dx.doi.org/10.1183/09031936.00038009 PMid:19880618
- M. Pareek, J.P. Watson, L.P. Ormerod, O.M. Kon, G. Woltmann, P.J. White, I. Abubakar, A. Lalvani, Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis, The Lancet infectious diseases, 11 (2011) 435-444. http://dx.doi.org/10.1016/S1473-3099(11)70069-X
- M. Pareek, M. Bond, J. Shorey, S. Seneviratne, M. Guy, P. White, A. Lalvani, O.M. Kon, Community-based evaluation of immigrant tuberculosis screening using interferon gamma release assays and tuberculin skin testing: observational study and economic analysis, Thorax, 68 (2013) 230-239. http://dx.doi.org/10.1136/thoraxjnl-2011-201542 PMid:22693179
- O. Oxlade, K. Schwartzman, D. Menzies, Interferon-gamma release assays and TB screening in high-income countries: a cost-effectiveness analysis, The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 11 (2007) 16-26.
- A. Mattelli, Case holding of TB in Europe:
does it matter if you are an immigrant?, Oral presentation at 7th
European Congress on Tropical Medicine & International Health, 3-6
October 2011. Ppt available at http://www.ectmihbarcelona2011.org/info.asp?apt=18, (2011).
- D. Zenner, J. Southern, R. van Hest, G.
DeVries, H.R. Stagg, D. Antoine, I. Abubakar, Active case finding for
tuberculosis among high-risk groups in low-incidence countries, The
international journal of tuberculosis and lung disease: the official
journal of the International Union against Tuberculosis and Lung
Disease, 17 (2013) 573-582 .
- M. Dara, P. de Colombani, R. Petrova-Benedict, R. Centis, J.P. Zellweger, A. Sandgren, E. Heldal, G. Sotgiu, N. Jansen, R. Bahtijarevic, G.B. Migliori, Minimum package for cross-border TB control and care in the WHO European region: a Wolfheze consensus statement, The European respiratory journal, 40 (2012) 1081-1090. http://dx.doi.org/10.1183/09031936.00053012 PMid:22653772 PMCid:PMC3485571
- A. Bissielo, E. Lim, H. Heffernan,
Tuberculosis in New Zealand: Annual Report 2011, Institute of
Environmental Science and Research Ltd (ESR): Wellington, New Zealand,
- Public Health Agency of Canada, Tuberculosis in Canada 2010, Pre-Release, Ottawa, (2012).
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