UPDATE ON THE LABORATORY DIAGNOSIS OF INVASIVE FUNGAL INFECTIONS

Brunella Posteraro, Riccardo Torelli, Elena De Carolis, Patrizia Posteraro, Maurizio Sanguinetti
  • Brunella Posteraro
    1Institute of Microbiology, Università Cattolica del Sacro, Italy
  • Riccardo Torelli
    Affiliation not present
  • Elena De Carolis
    Affiliation not present
  • Patrizia Posteraro
    Affiliation not present

Abstract

Recent advances in the management of patients with haematological malignancies and transplant recipients have paralleled an increase in the incidence of fungal diseases due to pathogenic genera such as Candida and Aspergillus and the emergence of less common genera including Fusarium and Zygomycetes. Despite availability of new antifungal agents these opportunistic infections have high mortality. Rapid and reliable species identification is essential for antifungal treatment, but detection of the increasing diversity of fungal pathogens by conventional phenotypic methods remains difficult and time-consuming, and the results may sometimes be inconclusive, especially for unusual species. New diagnostic techniques (e.g., 1,3-beta-d-glucan detection) could improve this scenario, although further studies are necessary to confirm their usefulness in clinical practice.


Keywords

Invasive fungal infections; Haematological patients; Conventional culture; Fungal antigen detection; Molecular methods

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Submitted: 2014-06-12 16:02:17
Published: 2011-01-03 00:00:00
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