CLINICAL ASPECTS AND THERAPY OF SPORADIC BURKITT LYMPHOMA

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Livio Pagano
Morena Caira *
Caterina Giovanna Valentini
Luana Fianchi
(*) Corresponding Author:
Morena Caira | morenacaira@yahoo.it

Abstract

Burkitt’s lymphoma is a highly aggressive mature B-cell neoplasm consisting of endemic, sporadic, and immunodeficiency-associated variants, that share many morphologic and immunophenotypic features. It is characterized by a high proliferation rate and propensity for extranodal sites such as gastrointestinal tract and reproductive organs. Brief-duration, high-intensity chemotherapy regimens including aggressive central nervous system prophylaxis have had remarkable success in the treatment of this disease in the sporadic form, with very high complete remission rate and overall survival  in adults. Although Burkitt's lymphoma is extremely chemosensitive, biologically targeted therapies should be developed, because current treatment options are suboptimal for patients with poor prognostic features or with relapsed disease.


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Author Biography

Livio Pagano, Catholic University ,Rome

Institute of Hematology, Catholic University, Associate Professor