HYDROXYCARBAMINE: FROM AN OLD DRUG USED IN MALIGNANT HEMOPATHIES TO A CURRENT STANDARD IN SICKLE CELL DISEASE

Giovanna Cannas, Solene Poutrel, Xavier Thomas
  • Giovanna Cannas
    Edouard Herriot Hospital Lyon, France
  • Solene Poutrel
    Edouard Herriot Hospital Lyon, France

Abstract

While hydroxycarbamine (hydroxyurea, HU) has less and less indications in malignant hemopathies, it represents the only widely used drug which modifies sickle cell disease pathogenesis. Clinical experience with HU for patients with sickle cell disease has been accumulated over the past 25 years in Western countries. The review of the literature provides increasing support of safety and efficacy in both children and adults for reducing acute vaso-occlusive events including pain episodes and acute chest syndrome. HU has become the standard-of-care for sickle cell anemia, but remains underused. Barriers to its use should be identified and overcome.

Keywords

hydroxyurea; treatment; sickle cell anemia; clinical management; hemoglobinopathies; prognosis.

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Published: 2017-02-15 00:00:00
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