Increased mortality in male recipients of red cells from ever pregnant female donors : mHAGs on red cells to blame ?

Kanjaksha Ghosh




mHag, Female to male transfusion , Death

Full Text:

Submitted: 2017-12-04 11:52:42
Published: 2018-01-01 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar


Blatyta PF, Custer B, Liu J, Mendrone-Junior A, Wright DJ, Leão SC, Lopes MI, Carneiro-Proietti AB, Sabino EC, de Almeida-Neto C; NHLBI Retrovirus EpidemiologyDonor Study-II (REDSII), International Component.The impact of policies to restrict the use of plasma containing products and apheresis platelets from female donors to mitigate transfusion-related acute lung injury (TRALI) in Brazil. Transfus Apher Sci. 2013; 48:15-20. PMid:22985535 PMCid:PMC3547161

Kolnagou A., Kontoghiorghe C.N., Kontoghiorghes G.J. Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor. Mediterr J Hematol Infect Dis 2017, 9(1): e2017060,

Caram-Deelder C, Kreuger AL, Evers D et al. Association of Blood Transfusion From Female Donors With and Without a History of Pregnancy With Mortality Among Male and Female Transfusion Recipients. JAMA. 2017; 318:1471-1478. PMid:29049654

Middelburg RA, Briët E, van der Bom JG. Mortality after transfusions, relation to donor sex. Vox Sang. 2011;101:221-9. PMid:21477152

Desmarets M, Bardiaux L, Benzenine E, et al. Effect of storage time and donor sex of transfused red blood cells on 1-year survival in patients undergoing cardiac surgery: an observational study. Transfusion 2016 ;56: 1213-22 PMid:26935140

Edgren G, Ullum H, Rostgaard K, et al. Association of Donor Age and Sex With Survival of Patients Receiving Transfusions. JAMA Intern Med. 2017;177:854-860.

Verdijk RM, Kloosterman A, Pool J, et al. Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy. Blood.2004; 103: 1961–4. PMid:14592836

Desmarets M, Cadwell CM, Peterson KR, Neades R, Zimring JC Minor histocompatibility antigens on transfused leuko reduced units of red blood cells induce bone marrow transplant rejection in a mouse model. Blood. 2009;114: 2315-22. PMid:19525479 PMCid:PMC2745850

Abstract views:


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Comments on this article

View all comments

Copyright (c) 2017 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185