Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia

Isabela Cristina Cordeiro Farias, Taciana Furtado Mendonça-Belmont, Andreia Soares Silva, Felipe Borba Ferreira, Fernanda Silva Medeiros, Luydson Richardson Silva Vasconcelos, Moacyr Jesus Barreto de Melo Rego, Marcos Andre Cavalcanti Bezerra, Aderson Silva Araujo, Patricia Muniz Mendes Freire Moura, Betânia Lucena Domingues Hatzlhofer, Ana Claudia Mendonça Anjos, Maria do Socorro Mendonça Cavalcanti
  • Taciana Furtado Mendonça-Belmont
    Affiliation not present
  • Andreia Soares Silva
    Affiliation not present
  • Felipe Borba Ferreira
    Affiliation not present
  • Fernanda Silva Medeiros
    Affiliation not present
  • Luydson Richardson Silva Vasconcelos
    Affiliation not present
  • Moacyr Jesus Barreto de Melo Rego
    Affiliation not present
  • Marcos Andre Cavalcanti Bezerra
    Affiliation not present
  • Aderson Silva Araujo
    Affiliation not present
  • Patricia Muniz Mendes Freire Moura
    Affiliation not present
  • Betânia Lucena Domingues Hatzlhofer
    Affiliation not present
  • Ana Claudia Mendonça Anjos
    Affiliation not present
  • Maria do Socorro Mendonça Cavalcanti
    Affiliation not present


The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology. 


Sickle cell anemia, vaso-occlusive crisis, splenic sequestration, SOD2 polymorphism

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Submitted: 2017-09-13 16:49:20
Published: 2018-02-21 00:00:00
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