of Pharmacy, The Second Affiliated Hospital of Chengdu Medical College,
China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan,
2 Department of Hematology, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China.
Received: January 22, 2020
Accepted: April 14, 2020
Mediterr J Hematol Infect Dis 2020, 12(1): e2020029 DOI 10.4084/MJHID.2020.029
| This is an Open Access article distributed
under the terms of the Creative Commons Attribution License
(https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The Iron chelation is essential to prevent iron overload damage of
vital organs, like heart, liver, and endocrine glands, in patients with
transfusion-dependent thalassemia. The most common chelation regimens
for β-thalassemia major (β-TM) patients used in China are a combination
therapy of deferoxamine and deferiprone (DFO+DFP), deferoxamine
(DFO) monotherapy, deferiprone (DFP) monotherapy and deferasirox (DFX)
monotherapy. Such patients use iron chelators their whole lives,
resulting in enormous treatment costs. This study analyses the
cost-utility of these four regimens from the Chinese healthcare system
β-thalassemia may be classified clinically as transfusion-dependent or non–transfusion-dependent.[7,8] β-TM patients require since early childhood regular red blood cell (RBC) transfusions to maintain adequate hemoglobin levels improving quality of life while reducing mortality.[7,8] Unfortunately, the human body does not have an iron excretory pathway, which leads to the accumulation of iron from the transfused blood, known as iron overload. The cumulative iron overload subsequently leads to organ toxic eﬀects and dysfunction, for example, in the heart, liver, or endocrine glands, eventually leading to death. Three iron chelators are currently available for the treatment of iron overload in β-TM patients: deferoxamine (DFO), deferiprone (DFP), and deferasirox (DFX). The four most commonly used chelation regimens in China are combination therapy of DFO and DFP (DFO+DFP) (38.9%), DFO monotherapy (19.1%), DFP monotherapy (19.0%) and DFX monotherapy (16.0%).
DFO was the first iron chelator to be marketed, and it is the first-line drug for β-TM patients 2 years of age and older. Because DFO is administered as a subcutaneous infusion, the quality of life and compliance of patients are low. Low compliance with DFO poses a higher risk of iron overload-related complications and death.[9,10] To obtain a higher quality of life, and better compliance, oral iron chelators, DFP and DFX, were introduced. DFP is the second-line drug for β-TM patients six years of age and older.[2,11] DFX is the first-line drug for patients 6 years of age and older in China and Europe.[2,12] Because cardiac complications related to iron overload is the leading cause of death in 52.3% of these patients, the guidelines of the US, Italy, Australia, and China all recommend that β-TM patients with iron overload-related cardiac complications should receive DFO+DFP.[11,14-16]
Because β-TM patients need to use iron chelators throughout their whole lives, the treatment cost is enormous. Paramore et al. reported that the annual average chelation treatment cost of transfusion-dependent β-thalassemia patients in the US was approximately USD 53,000. Esmaeilzadeh et al. found that the treatment of approximately 18,000 β-TM patients led to an annual loss of nearly USD 150 million for Iran's healthcare system. In China, the annual average treatment cost of blood transfusion and iron excretion for β-TM patients was over CNY 100,000, but the annual income of over 90% of families with β-TM patients was less than CNY 60,000, which means that most families with β-TM patients will fall into poverty due to the illness. As a result, it is crucial to analyse the cost-effectiveness of iron chelation regimens from a Chinese perspective.
According to a previous systematic review, there is no published analysis of the relative cost-effectiveness of iron chelator therapies from a Chinese perspective. Cost-effectiveness is not an entire issue when in different countries (regions), the results are the opposite for other countries (regions). The specific legislation of regions where clinicians operate has a substantial influence on the economics of drugs. Thus, this study aims to compare the cost-utility of the four iron chelation regimens (DFO, DFP, DFX, DFO+DFP) from the Chinese healthcare system perspective.
Outline of the economic model. The model considered adults and children, regardless of treatment history or disease status. A 5-year time horizon was specified in the model, and the cycle length was one year. The People's Bank of China regulates that for financial institutions, the national guiding interest rate for one-year deposits is 1.5%. Hence, we used a 1.5% discount rate to discount future costs and QALYs (quality-adjusted life year). The National Bureau of Statistics of China announced that in 2018, per capita GDP was CNY 64,644.
Additionally, a study by the World Health Organization (WHO) proposed that when the incremental cost-effectiveness ratio (ICER) was less than three times per capita GDP, the increased costs were acceptable, and the intervention was cost-effective. As a result, the payment threshold used in the model was CNY 193,932. We constructed our Markov model with three health statuses: β-thalassemia without cardiac complications, β-thalassemia with cardiac complications, and death (Figure 1). In addition to the cardiac complication, the major complications of iron overload include chronic liver disease, diabetes mellitus, hypogonadism, hypoparathyroidism, and hypothyroidism.[19,23,24] The cost and morbidity of these complications were also calculated in a model.
|Figure 1. Markov model.|
Systematic literature review. A systematic literature search in MEDLINE (PubMed), EMBASE (Ovid), the Cochrane Central Register of Controlled Trials (CENTRAL, Cochrane Library), the Cochrane Database of Systematic Reviews (CDSR, Cochrane Library), China Biology Medicine (CBM, SinoMed), the China National Knowledge Infrastructure (CNKI), VIP Data, and Wanfang Data was conducted on March 2019, with no restrictions on the date. Besides, a manual search was performed to identify conferences. Both Chinese and English search terms were used. The search terms included “thalassemia”, “beta-thalassemia”, “iron overload”, “iron-chelating agents”, “deferoxamine”, “deferiprone”, and “deferasirox” and their variations. The study selection and data extraction were conducted independently by two researchers to confirm that they met the pre-defined inclusion/exclusion criteria and data extraction form. Any inconsistencies were resolved through discussion. The inclusion criteria for the systematic review were as follows: population: β-TM patients or transfusion-dependent thalassemia major patients; intervention/comparison: DFO, DFP, DFX, or DFO+DFP; outcomes: (1) clinical data: cardiac complication morbidity, cardiac complication mortality, and non-cardiac complication mortality; (2) utility data: the utility associated with cardiac complication or without cardiac complication; and (3) cost data: the chelator cost, DFO administration cost, cardiac complication therapy cost, and monitoring cost; study design: randomized controlled trials (RCTs), non-RCTs, observational studies, and pharmacoeconomic reviews. Because local/national context has a substantial influence on the results of pharmacoeconomic evaluations, we used valuable localized in this study. For the clinical data, we preferred to use data from China (including Mainland China, Hong Kong, Macao, and Taiwan), followed by data from Asia or all around the world. For the utility data, we used data from China (including Mainland China, Hong Kong, Macao, and Taiwan). For the cost data, we used data from Mainland China.
Data used in the model. The detailed data were shown in Table 1.
|Table 1. Values used in the model.|
a) Chelator cost: The chelator cost was calculated according to the drug cost, chelator dosage, and patient weight. Lau et al. reported that the mean weight of 381 TM (age ranging from 3 months to 56 years) was 46.5kg, and it was used in the model. We searched the official websites of 31 provincial-level administrative units in Mainland China to obtain the government wholesale acquisition cost. The average unit cost of drugs was used in the model. The government official websites showed that there were only brand-name drugs: Desferal®, Ferriprox®, and Exjade®. Luangasanatip et al. reported that the cost of the generic version of DFO, USD 0.20 per gram, was only 9.57% that of the brand-name drug (USD 2.09 per gram). As a result, we used 10% of the average unit cost of drugs in a sensitivity analysis. In this study, we assumed that the patient compliance rate was 100%. The dosage levels and frequencies of the four iron chelation regimens were based on Chinese guidelines.[11,27] The average dosage was used in the base-case analysis. The maximum dosage and minimum dosage were used in the sensitivity analysis.
b) DFO administration cost: We searched the official websites of 31 provincial-level administrative units in Mainland China to obtain the DFO administration cost. The average cost was used for the base-case analysis, while the maximum cost was used in the sensitivity analysis. If DFO patients purchased an infusion pump and used it at home, the DFO administration was free. Therefore, CNY 0 was used in the sensitivity analysis.
c) Monitoring cost: Reduction of severe adverse reactions requires that the vision and hearing of patients on DFO therapy should be monitored every three months, the blood cell count of patients on DFP therapy should be monitored weekly,[27,29] and the renal function of patients on DFX therapy should be monitored monthly.[27,12] We searched the official websites of 31 provincial-level administrative units in Mainland China to obtain those monitoring costs. The average cost was used for the base-case analysis, while the minimum and maximum costs were used in the sensitivity analysis.
d) Complications therapy cost: Luangasanatip et al. reported that the cost of treating iron overload-related cardiac complications in thalassemia patients was the same as the cost of treating chronic heart failure complications in patients with diabetes mellitus. In China, the annual medical cost of treating chronic heart failure complications in patients with type 2 diabetes mellitus was CNY 9897.37 and the data were used in the model. We used the cost data of hypogonadism, hypoparathyroidism, and hypothyroidism from Ho et al. The rate was USD 1= CNY 7.0328.
Utility data. Eighteen patients (32 person-time) who were treated at a hospital between 2015 and 2017 completed an assessment to get their utility values for DFO (12 person-time), DFP (9 person-time), and DFX (11 person-time) by a time trade-off (TTO) method. Participants were queried to identify the number of years of life with β-TM treated with either DFO, DFP, or DFX that they would be willing to trade off for years of life with perfect health. The average utility was used in the model. Kuo et al. reported that the utility value for DFO+DFP. For patients with cardiac disease, their quality of life is estimated to be approximately 15% less than that of individuals without cardiac disease.
Clinical data. From the systematic review, there was one paper from China reported cardiac complication morbidity and mortality with DFX, where the morbidity was 7.7%, and mortality was 100% over 2 years. Three reported cardiac complication morbidity and mortality with DFO from Asia.[35-37] Ayyub et al. reported cardiac complication morbidity and mortality with DFP from Pakistan, where the morbidity was 54.5%, and mortality was 16.7% over 3 years. Tanner et al. paper reported cardiac morbidity with DFO+DFP, where the morbidity was 13.3% over one year. There was one paper reported non-cardiac complication mortality with DFO from Iran, where the mortality was 4.0% over 5 years. However, there were two papers reported non-cardiac complication mortality from Europe, where the mortality was 2.6% over 3 years with DFP and 1.0% over 6.9 years with DFX respectively. These were converted into an annual rate for use in the model using actuarial life-table methods; the mean of different annual rates with the same iron chelation was used in the model. The morbidity of diabetes mellitus, hypogonadism, and hypothyroidism were both reported from China,[44-50] and the mean of different morbidity was used in the model.
Sensitivity analysis. One-way sensitivity analysis was performed to investigate the effects of altering the parameters, including the dosage, costs, utilities, and transition probabilities, within plausible ranges. To assess the main drivers of cost-effectiveness, we generated tornado diagrams representing the one-way sensitivity analysis for each comparison combination (DFO+DFP versus DFO, DFO+DFP versus DFP, DFO+DFP versus DFX, DFX versus DFO, DFX versus DFP and DFP versus DFO). A tornado diagram plotted the results of the effects of the ten most influential parameters on the outcomes from a sensitivity analysis exercise. These parameters were ordered such that the most influential parameter is at the top of the tornado diagram. In addition, all parameters were simultaneously varied in a probabilistic sensitivity analysis in which the doses and costs assumed to follow gamma distributions, while the utilities and transition probabilities were assigned beta distributions, in line with best practices.[52,53]
To analysis the influence of these key parameters of the one-way sensitivity analysis, which resulted in an ICER being greater or less than the payment threshold, we valued and calculated the fraction of these. Firstly, we valued key parameters according to the influence in each comparison. The most influential key parameter was valued 10, decreasing successively, and the least influential key parameter was valued 1. Secondly, we added up the value of the key parameter.
|Table 2. Results of base-case analysis.|
Sensitivity analysis. One-way sensitivity analysis. The one-way sensitivity analysis results are represented in tornado diagrams in Figure 2.
For DFX versus DFO (tornado diagram A.), the patient weight and DFX drug cost resulted in an ICER＜payment threshold, indicating that DFO was not cost-effective.
For DFX versus DFP (tornado diagram B.), the patient weight and DFX drug cost resulted in an ICER＜payment threshold, indicating that DFP was not cost-effective.
For DFX versus DFO+DFP (tornado diagram C.), the DFO drug cost, DFX dose, utility without cardiac complication of DFO+DFP, utility without cardiac complication of DFX, DFP drug cost, patient weight, utility with cardiac complication of DFO+DFP resulted in an ICER>payment threshold, indicating that DFX was not cost-effective.
For DFO+DFP versus DFO (tornado diagram D.), the utility without cardiac complication of DFO, utility without cardiac complication of DFO+DFP and patient weight resulted in an ICER<payment threshold, indicating that DFO was cost-effective.
For DFO+DFP versus DFP (tornado diagram E.), the utility without cardiac complication of DFO+DFP, utility without cardiac complication of DFP, and patient weight resulted in an ICER<payment threshold, indicating that DFP was cost-effective.
For DFP versus DFO (tornado diagram F.), the cardiac complication mortality of DFP, cardiac complication morbidity of DFP, utility with cardiac complication of DFO, DFO drug cost resulted in an ICER>payment threshold, indicating that DFP was not cost-effective.
Probabilistic sensitivity analysis. Figure 3 shows the results of the probabilistic sensitivity analysis, represented by scatter plots. We simulated 10,000 sets of doses, costs, utilities, and transition probabilities estimated for each strategy by simultaneously sampling from the assigned probability distributions of the variables. At the payment threshold, 193,932.00 CNY/QALY, compared with DFX, DFO+DFP, and DFO, the likelihood of DFP being cost-effective was 97.32%, 99.43% and 58.04%. Compared with DFX and DFO+DFP, the likelihood of DFO being cost-effective was 92.84% and 98.01%. Compared with DFO+DFP, the likelihood of DFX being cost-effective was 53.97%.
|Figure 3. Scatter plots for the probabilistic sensitivity analyses of A. DFX versus DFO, B. DFX versus DFP, C. DFX versus DFO+DFP, D. DFO+DFP versus DFO, E. DFO+DFP versus DFP and F. DFP versus DFO.|
The influence of key parameters of the one-way sensitivity analysis. The calculation results of the influence of key parameters of the one-way sensitivity analysis were shown in Table 3.
|Table 3. The influence of key parameters of the one-way sensitivity analysis.|
A systematic literature review of the cost-effectiveness of the four chelation regimens for β-TM showed that DFP was the dominant strategy, which was consistent with the findings of this study. In the systematic literature review, DFX and DFO were tied as the second most cost-effective treatment regimen, and we could not judge which one was more cost-effective. In our study, DFO was the second most cost-effective treatment regimen, and DFP was the third. The systematic literature review and our study both thought DFO+DFP was the least cost-effective treatment regimen.
The one-way sensitivity analysis results and the influence of key parameters of the one-way sensitivity analysis reported that the utility without cardiac complication of DFO+DFP, DFX drug cost, DFO drug cost, cardiac complication mortality of DFP and the utility without cardiac complication of DFO were important. As a result, we have some suggestions to save more on costs or to obtain more QALYs. Firstly, for the Chinese government, DFX and DFO drug cost needs to be reduced. The available measures included incorporating these drugs into the National Reimbursement Drug List, negotiating drug prices, imposing a zero tariff on imported chelators, and encouraging the development of generic drugs. For Chinese clinicians, the following measures can be taken: (1) choosing the DFX and DFO that is cheaper or that is incorporated into the National Reimbursement Drug List to make the drug cost lower, (2) acting in accordance with patients’ parameters to make the utility of drugs higher(especially DFO+DFP), and (3) standardizing the use of chelators to reduce morbidity and mortality (especially DFP).
The results of the probabilistic sensitivity analysis showed that the likelihood of DFX being cost-effective compared to DFO+DFP was 63.97%, and the likelihood of DFP being cost-effective compared to DFO was 58.04%. These findings meant that changes in influential parameters easily changed the results of DFX versus DFO+DFP and DFP versus DFO. The key parameters of DFX versus DFO+DFP and of DFP versus DFO were shown in Figure 2. As a result, clinicians should pay more attention to the key parameters to save more on costs or to obtain more QALYs.
Generally, one utility is used for oral iron chelation therapy (DFP or DFX), and a different utility is used for the subcutaneous infusion. However, in our study, the utility of DFP was different from DFX. The main reason for the difference was that some patients who used DFP had experienced severe adverse reactions. In other papers, this difference also existed. Luangasanatip et al. reported that the utility of DFP and DFX was 0.61 and 0.85, respectively.
We needed data on the cardiac complication morbidity, cardiac complication mortality, and non-cardiac complication mortality of the four chelation regimens from China (including Mainland China, Hong Kong, Macao, and Taiwan) to input them into the Markov model. Unfortunately, at the time of the study, there were not enough clinical data from China. To ensure the quality of this study, we performed a systematic literature review and used clinical data from the rest of the world. The clinical data may vary among different races. Therefore, they may bias the results.
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