Case Reports
Vol. 9 No. 1 (2017): Review, Original Articles, Case Reports
Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: October 3, 2016
Accepted: December 7, 2016
Accepted: December 7, 2016
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Haematology
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Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However there is paucity of data about its efficacy and safety in beta-thalassaemia major (?-TM).
This retrospective case series of five patients (mean age of 45 years) is the first study evaluating the use of sitagliptin in patients with ?-TM and DM.
Four patients responded well to sitagliptin, as evidenced by decrease in fructosamine by 77 and 96µmol/L (equivalent reduction in HbA1c of 1.5% and 1.9%) observed in two patients and reduction in the frequency of hypoglycaemia without worsening glycaemic control in two others. One patient did not respond to sitagliptin. No patients reported significant side effects.
This study provides evidence that sitagliptin may be considered, with caution, for use in patients with ?-TM and DM, under the close monitoring of a Diabetologist.
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Case ReportHow to Cite
“Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series” (2017) Mediterranean Journal of Hematology and Infectious Diseases, 9(1), p. e2017004. doi:10.4084/mjhid.2017.004.
