Giuseppe Vittorio De Socio
Clinica di Malattie Infettive, Università degli Studi di Perugia
Ospedale "Santa Maria della Misericordia", piazzale Menghini, 1 – 06129 Perugia, Italy
Phone: +39-075-5784321 • Fax: +39-075-5784346 • E-mail: giuseppedesocio@yahoo.it
Antonio D'Avolio
Laboratory of Clinical Pharmacology and Pharmacogenetic, Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy
Alessio Sgrelli
Clinica di Malattie Infettive, Università degli Studi di Perugia
Ospedale "Santa Maria della Misericordia", piazzale Menghini, 1 – 06129 Perugia, Italy
Lorena Baietto
Laboratory of Clinical Pharmacology and Pharmacogenetic, Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy
Lisa Malincarne
Clinica di Malattie Infettive, Università degli Studi di Perugia
Ospedale "Santa Maria della Misericordia", piazzale Menghini, 1 – 06129 Perugia, Italy
Giovanni Di Perri
Laboratory of Clinical Pharmacology and Pharmacogenetic, Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy
Franco Baldelli
Clinica di Malattie Infettive, Università degli Studi di Perugia
Ospedale "Santa Maria della Misericordia", piazzale Menghini, 1 – 06129 Perugia, Italy
Keywords
tuberculosis, gastrectomy, high performance liquid chromatography, therapeutic drug monitoring.
Abstract
We report pharmacokinetic data on two gastrectomized, patients affected by tuberculosis. Drugs plasmatic concentrations were measured after seven days of oral therapy by a validated high performance liquid chromatography-mass spectrometry (HPLC-MS) method and the area under the concentration-time-curve (AUC) over 24 hours (AUC0-24) was calculated. A sub-therapeutic level of isoniazid was found in a patient with total gastrectomy with a Cmax of 0,395 mg\L and AUC0-24 level of 4.75 hr*mg/L. The level of the other antitubercular drugs was adequate. Measurement of drug level in gastrectomy patients with tuberculosis is warranted.
