Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report

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puneet chhabra
junior resident department of internal medicine PGIMER CHANDIGARH 160012

arjun dutt law
senior resident department of internal medicine PGIMER CHANDIGARH 160012

dr vikas suri
assistant professor department of internal medicine PGIMER CHANDIGARH 160012

dr pankaj malhotra
additional professor department of internal medicine PGIMER CHANDIGARH 160012

dr subhash varma
HOD and professor department of internal medicine PGIMER chandigarh

Keywords

methotrexate, lung in jury, primary CNS lymphoma

Abstract

Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.

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Published
Apr 2, 2012
DOI https://doi.org/10.4084/mjhid.2012.020

Article Details

How to Cite

chhabra, puneet (2012) “Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report”, Mediterranean Journal of Hematology and Infectious Diseases, 4(1), p. e2012020. doi: 10.4084/mjhid.2012.020.
Issue
Vol. 4 No. 1 (2012): Reviews, Articles, Case Reports and Letters
Section
Case Reports

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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