INCIDENCE OF ACUTE MYELOID LEUKEMIA AFTER BREAST CANCER

Caterina Giovanna Valentini, Luana Fianchi, Maria Teresa Voso, Morena Caira, Giuseppe Leone, Livio Pagano
  • Caterina Giovanna Valentini
    Catholic University ,Rome, Italy
  • Luana Fianchi
    Affiliation not present
  • Maria Teresa Voso
    Affiliation not present
  • Morena Caira
    Affiliation not present
  • Livio Pagano
    Affiliation not present

Abstract

Breast cancer is the most frequent cancer among women and the leading cause of death among middle-aged women. Early detection by mammography screening and improvement of therapeutic options have increased breast cancer survival rates, with the consequence that late side effects of cancer treatment become increasingly important. In particular, patients treated with adjuvant chemotherapy regimens, commonly including alkylating agents and anthracyclines, are at increased risk of developing leukemia, further enhanced by the use of radiotherapy. In the last few years also the use of growth factors seems to increase the risk of secondary leukemia. The purpose of this review is to update epidemiology of therapy-related myeloid neoplasms occurring in breast cancer patients

Keywords

Leukemia, breast cancer, therapy related neoplasm, secondary leukemias

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Submitted: 2014-06-12 16:03:21
Published: 2011-12-22 00:00:00
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