Tuberculosis after gastrectomy, plasmatic concentration of antitubercular drugs

Giuseppe Vittorio De Socio, Antonio D'Avolio, Alessio Sgrelli, Lorena Baietto, Lisa Malincarne, Giovanni Di Perri, Franco Baldelli
  • Giuseppe Vittorio De Socio
    Clinica di Malattie Infettive, Università degli Studi di Perugia Ospedale "Santa Maria della Misericordia", piazzale Menghini, 1 – 06129 Perugia, Italy Phone: +39-075-5784321 • Fax: +39-075-5784346 • E-mail: giuseppedesocio@yahoo.it, Italy | giuseppedesocio@yahoo.it
  • Antonio D'Avolio
    Laboratory of Clinical Pharmacology and Pharmacogenetic, Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy, Italy
  • Alessio Sgrelli
    Clinica di Malattie Infettive, Università degli Studi di Perugia Ospedale "Santa Maria della Misericordia", piazzale Menghini, 1 – 06129 Perugia, Italy, Italy
  • Lorena Baietto
    Laboratory of Clinical Pharmacology and Pharmacogenetic, Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy,
  • Lisa Malincarne
    Clinica di Malattie Infettive, Università degli Studi di Perugia Ospedale "Santa Maria della Misericordia", piazzale Menghini, 1 – 06129 Perugia, Italy, Italy
  • Giovanni Di Perri
    Laboratory of Clinical Pharmacology and Pharmacogenetic, Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy,
  • Franco Baldelli
    Clinica di Malattie Infettive, Università degli Studi di Perugia Ospedale "Santa Maria della Misericordia", piazzale Menghini, 1 – 06129 Perugia, Italy, Kiribati

Abstract

We report pharmacokinetic data on two gastrectomized, patients affected by tuberculosis. Drugs plasmatic concentrations were measured after seven days of oral therapy by a validated high performance liquid chromatography-mass spectrometry (HPLC-MS) method and the area under the concentration-time-curve (AUC) over 24 hours (AUC0-24) was calculated. A sub-therapeutic level of isoniazid was found in a patient with total gastrectomy with a Cmax of 0,395 mg\L and AUC0-24 level of 4.75 hr*mg/L. The level of the other antitubercular drugs was adequate. Measurement of drug level in gastrectomy patients with tuberculosis is warranted.

Keywords

tuberculosis, gastrectomy, high performance liquid chromatography, therapeutic drug monitoring.

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Submitted: 2014-06-13 09:32:36
Published: 2012-01-23 00:00:00
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