Epstein-Barr Virus (EBV)-associated Haemophagocytic Syndrome

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Lorenza Torti
Luigi Maria Larocca
Giuseppina Massini
Luciana Teofili


EBV, hemophagocytic syndrome


We describe the case of a 17- year old female who developed fatal haemophagocytic syndrome (HPS) one month following acute infection caused by Epstein-Barr virus (EBV). Despite initiation of treatment and reduction of EBV load, laboratory signs of HPS as severe cytopenia, hypofibrinogenemia, hyperferritinemia and hypertriglyceridemia persisted, and the patient died of multiorgan failure. HPS is a rare, but life-threatening complication of EBV infection.


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