Systemic granulomatous reaction secondary to treatment of bladder cancer with Bacillus Calmette-Guerin

Caterina Giovanna Valentini, Valentina Bozzoli, Anna Rita Larici, Luigi Maria Larocca, Giovanni Delogu, Giuseppe Leone, Livio Pagano
  • Valentina Bozzoli
    Affiliation not present
  • Anna Rita Larici
    Affiliation not present
  • Luigi Maria Larocca
    Affiliation not present
  • Giovanni Delogu
    Affiliation not present
  • Giuseppe Leone
    Affiliation not present
  • Livio Pagano
    Affiliation not present


Intravesical instillation of Bacillus Calmette-Guérin is the elective treatment for transitional cell and in situ bladder carcinoma. Severe complications occur very seldom, but must be known and promptly recognized. We describe the case of a 48-year-old man, treated with chemo-immunotherapy ten years before for a follicular lymphoma, who developed a systemic granulomatous reaction after his twelfth intravescical BCG instillation for bladder cancer.


granulomatous hepatitis; bone marrow granulomatosis; Bacillus Calmette-Guerin; bladder carcinoma; lymphoma

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Submitted: 2014-06-13 09:33:35
Published: 2012-06-18 00:00:00
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