Systemic granulomatous reaction secondary to treatment of bladder cancer with Bacillus Calmette-Guerin

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Caterina Giovanna Valentini
Valentina Bozzoli
Anna Rita Larici
Luigi Maria Larocca
Giovanni Delogu
Giuseppe Leone
Livio Pagano


granulomatous hepatitis, bone marrow granulomatosis, Bacillus Calmette-Guerin, bladder carcinoma, lymphoma


Intravesical instillation of Bacillus Calmette-Guérin is the elective treatment for transitional cell and in situ bladder carcinoma. Severe complications occur very seldom, but must be known and promptly recognized. We describe the case of a 48-year-old man, treated with chemo-immunotherapy ten years before for a follicular lymphoma, who developed a systemic granulomatous reaction after his twelfth intravescical BCG instillation for bladder cancer.


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