Mantle cell lymphoma relapsing at the lymphedematous arm.

Giuseppina Massini, Stefan Hohaus, Francesco D'Alo', Valentina Bozzoli, Barbara Vannata, Luigi Maria Larocca, Luciana Teofili
  • Giuseppina Massini
    Affiliation not present
  • Stefan Hohaus
    Affiliation not present
  • Francesco D'Alo'
    Affiliation not present
  • Valentina Bozzoli
    Affiliation not present
  • Barbara Vannata
    Affiliation not present
  • Luigi Maria Larocca
    Affiliation not present


Lymphedema (LE) is a chronic medical condition characterized by lymphatic fluid retention, resulting in tissue swelling. Cancer treatments involving lymph nodes can damage lymph drainage routes, causing accumulation of lymph fluid in the interstitial tissue of related limbs and body areas and secondary LE.  Basically, the LE has a negative impact on physical and mental quality of life. Moreover, 0.07-0.04% of long term survivors (most patients undergone mastectomy) can develop the Stewart-Treves syndrome,  a rare and aggressive multifocal lymphangiosarcoma arising within the LE region. Here we describe a   45-year-old woman  with a massive LE of the left arm,  as a consequence of previous breast cancer,  who  was diagnosed after 4 years  of stage IV mantle cell lymphoma (MCL) . The patient after obtaining complete remission with chemotherapy and ABMT  relapsed of MCL in lymphedema site.


Lymphoma, Lymphedema

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Submitted: 2014-06-13 09:59:58
Published: 2013-02-16 00:00:00
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