VASCULAR ENDOTHELIAL GROWTH FACTOR IN CHILDREN WITH THALASSEMIA MAJOR PDF

sameh samir fahmey, Hassan Naguib, sanna Abdelshafy, rasha Alashry
  • Hassan Naguib
    Pediatrics Department ,Beni Suef University, Egypt
  • sanna Abdelshafy
    clinical pathology Department ,Beni Suef University, Egypt
  • rasha Alashry
    Pediatrics Department ,Beni Suef University, Egypt

Abstract

Background: The β-Thalassemia syndromes are the most common hereditary chronic hemolytic anemia due to impaired globin chain synthesis.  Vascular endothelial growth factor (VEGF) plays several roles in angiogenesis which is a crucial process in the pathogenesis of several inflammatory, autoimmune and malignant diseases .Endothelial damage and inflammation make a significant contribution to the pathophysiology of β-thalassemia.

Purpose: The aim of the study was to assess serum VEGF level in children with beta-thalassemia major as a marker of angiogenesis.

Methods: Blood samples were collected from 40 patients with thalassemia major and 10 healthy controls and assayed for VEGF by enzyme-linked immunosorbent assay.

Results: VEGF level was significantly higher in patients with β-Thalassemia major than healthy controls (p=0.001).In addition, VEGF level was higher in splenectomised thalassemic patients than non splenectomised ones (p=0.001) .However, there were a positive correlation between VEGF and chelation starting age (p=0.008) and a negative correlation between VEGF and frequency of blood transfusion (p=0.002).

Conclusion: thalassemia patients, especially splenectomized, have elevated serum levels of VEGF. Early chelation and regular blood transfusion help to decrease serum VEGF and the risk of angiogenesis.

 

Keywords

anemia, angiogenesis, splenectomy, thalassemia major

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Submitted: 2014-06-13 09:58:14
Published: 2013-06-05 00:00:00
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