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Escherichia coli (E. coli) is a pathogen of great concern in immunosuppressed patients. While antimicrobial prophylactic therapy has become the standard, the emergence of resistant pathogens has some questioning its use. This study describes our experience with E.coli as a pathogen in neutropenic patients with a hematologic malignancy, and addresses future directions of treatment for this patient population.
A retrospective chart review of 245 E.coli bacteremia patients at Moffitt Cancer Center from 05/18/02 – 05/15/12 was conducted. Patients were identified via microbiology laboratory computerized records.
The included patients experienced clinically significant E.coli bacteremia resulting in a median hospital stay of 14.7 days. Several patients developed severe sepsis requiring the use of pressor and ventilator therapy.
E.coli is a major pathogen in these patient populations resulting in extended hospital stays and specialized treatment to overcome their E.coli bacteremia. The data supports the use of fluoroquinolone prophylactic therapy, however, earlier detection and treatment of neutropenic infection is needed.
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John Norman Greene, Section Chief, Division of Infectious Diseases and Tropical Medicine - Moffitt Cancer Center, Tampa FL Professor of MedicineBIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
John N. Greene MD FACP
Professor, Division of Infectious Disease & International Medicine
eRA COMMONS USER NAME (credential, e.g., agency login)
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION
FIELD OF STUDY
College of William and Mary, Williamsburg, Virginia
Biology and Psychology
University of South Florida College of Medicine,
University of South Florida College of Medicine, Tampa, Florida
University of South Florida College of Medicine, Tampa, Florida
A. Personal Statement
Dr. John N. Greene received his medical degree from the University of South Florida College of Medicine, Tampa, Florida. He is a Professor of Medicine and currently the Section Chief, Division of Infectious Diseases and Tropical Medicine and Senior Member of the Blood & Marrow Transplant department at Moffitt Cancer Center, Tampa, FL. He is affiliated with numerous committees, community outreach projects, associations, and boards. He is an accomplished speaker and writer, having published over 166 manuscripts in peer reviewed journals and has been a speaker for over 160 invited presentations. He has written and published one book, and written over 30 chapters in other books. Dr. Greene has been a mentor to hundreds of medical students throughout his career and has taken many students with him on his yearly medical mission trips to third world countries
B. Positions and Honors
1994-present “Moffitt Angel” Award (Patients’ Family Request).
1996-present Citation, “The Best Doctors in America: Southeast Region.”
1997 Physician of the Year, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
1998 “Doctor of the Day”, Florida Senate, Tallahassee, FL
2003 Nomination for “Outstanding Sophomore Instructor” by the graduating class, University of South Florida College of Medicine, Tampa, FL
2003 “The Leonard Tow 2003 Humanism in Medicine” Award, “In Recognition of Exemplary Compassion, Competence and Respect in the Delivery of Care,” The Arnold P. Gold
2005 Election to the Gold Humanism Honor Society in Recognition of Exemplary Service to Others
2006 USF Department of Internal Medicine Faculty Award for H. Lee Moffitt Resident Teaching Award.
2007-2008 Selected by peers “Best Doctors in America® 2007-2008”
2008-2009 Biographical candidate representing industry in the Who’s Who Among Executives and Professionals “Honors Edition”
2009-2010 Selected by peers “Best Doctors in America® 2009-2010”
2010-2011 Who’s Who of Executives Professionals and Entrepreneurs 2010-2011
C. Selected Peer-reviewed Publications
Marela Velez, Beata Casanas, John N. Greene*, Jose Morey, Dominick Mastroianni, Richard Oehler – Pasteurella multocida Infections in Cancer Patients - Asian Biomedicine Vol. 4 No. 3 June 2010; 449-455
Pham T, Greene JN*, Sandin RL, Vincent AL, Messina J. – A Chronic Nodular Hand and Forearm Lesion - Infectious Diseases in Clinical Practices “Images in ID – What’s Your Diagnosis? – Vol. 18, No. 4, July 2010; 261-263
Knapp CF, Tucci VT, Keeler JA, Sandin RL, Greene JN*, - Primary Cutaneous Acremonium Infection in a Neutropenic Patient After Trauma – Infectious Diseases in Clinical Practices – Vol. 18, No. 4, July 2010; 277-278
Choudhry A, Tucci V, Greene JN*, - Disseminated Bipolaris Infection – Review Article: Infectious Diseases in Clinical Practices Vol. 18, No. 5, September 2010; 296-298
Li, Y, Greene JN, Sandin RL, - “Recurrent Soft Tissue Infection Seventy Years After Initial Trauma”. – Images in ID – What’s the Diagnosis? Infectious Diseases in Clinical Practice, November 2010:18:389-391
Greene JN – Prevention of Infections in Patients with Hematologic Malignancies – The spectrum of infections is changing as microbes take advantage of neutropenia – National Comprehensive Cancer Network (NCCN) 5th Annual Congress: Hematologic Malignancies 2010, pages 30-33
Rivera, RJ, Alrabaa, SF, List, A, Greene, JN*., “Successful Treatment of Refractory Disseminated Mycobacterium Abscessus infection using Gamma Interferon” – Case Report - Infections Diseases in Clinical Practices – Vol. 19, Issue 2, March 2011;142-145
Prince MD, Suber JS, Aya-ay ML, Cone Jr. JD, Greene JN, Smith Jr. DJ, Smith PD, - “Prosthesis Salvage in Breast Reconstruction Patients with Periprosthetic Infection and Exposure” Plas. Reconstr. Surg. 129: 42, June 2012
Lortholary O, Obenga G, Biswa P, Cailott D, Chachaty E, Bienvenu AL, Cornet M, Greene JN, Herbert R, Lacroix C, Grenouillet F, Raad I, Sitbon K, Troke P; the French Mycoses Study Group – An International, Retrospective Analysis of 73 Cases of Invasive Fusariosis Treated with Voriconazole – Antimicrobial Agents Chemotherapy, Vol. 54, No. 10, Oct. 2011, p. 4446-4450
Stein, M, Palumbo, B., Letson, DG, Bui, MM, Sandin, RL, Greene, JN – Case Report – “A Case of Coccidioides Synovitis of the Knee Presents Clinically as Pigmented Villonodular Synovitis” Infectious Diseases in Clinical Practice. (1)6:439-441, November 2011
Osterndorf B., Oehler RL, Greene JN – Case Report “Human Staphylococcus intermedius Infection in a Patient with Post-radiation Changes – Infectious Diseases in Clinical Practices 19(6);426-427, November 2011
Prince MD, Suber JS, Aya-Ay ML, Cone JD Jr, Greene JN, Smith DJ Jr, Smith PD. Prosthesis salvage in breast reconstruction patients with periprosthetic infection and exposure. Plast Reconstr Surg. 2012 Jan;129(1):42-8. PubMed PMID: 22186499.Manry, Matthew; Cox, Jennifer; Casanas, Beata; Quilitz, Rod; Greene, John N. Rituximab-Associated Occurrence of Disseminated Miliary Tuberculosis Infectious Diseases in Clinical Practice. 20(1):82-84, January 2012.
Givins P, Velez AP, Sandin RL, Quilitz RE, Greene JN* – Development of Enteroviral Meningoencephalitis Following Rituximab Treatment for Non-Hodgkin’s Lymphoma - Infectious Diseases in Clinical Practice - July 2012;20(4):291-293
Casanas BC, Kass J, Pathak A, Tucci V, Payor A, Vincent AL, Greene JN*, Sandin RL, - 1 Non-gastrointestinal Aeromonas Hydrophilia Infections in Cancer Patients – Infectious Diseases in Clinical Practice – July 2012;20(4):268-271
D. Research Support