High level of HBV DNA virus in the breast milk seems not to contraindicate breastfeeding

Ana Montoya-Ferrer, Astrid Marina Zorrilla, Johannes Viljoen, Jean Pierre Moles, Marie-Louise Newell, Philippe Van de Perre, Edouard Tuaillon
  • Ana Montoya-Ferrer
    Département des Maladies Infectieuses et Tropicales, Centre Hospitalier Régional Universitaire de Montpellier, France, France | a-montoyaferrer@chu-montpellier.fr
  • Astrid Marina Zorrilla
    University of Florida College of Medicine, Gainesville, Florida, United States, United States
  • Johannes Viljoen
    Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Durban, South Africa, South Africa
  • Jean Pierre Moles
    Université Montpellier 1, Inserm U1058, Montpellier, France, France
  • Marie-Louise Newell
    Faculty of Medicine, University of Southampton, Southampton, United Kingdom
  • Philippe Van de Perre
    Département de Bactériologie-Virologie, Centre Hospitalier Universitaire de Montpellier, France, France
  • Edouard Tuaillon
    Département de Bactériologie-Virologie, Centre Hospitalier Universitaire de Montpellier, France, France


Concerns of possible risk of mother to child HBV transmission through breastfeeding arouse when mothers present high levels of HBV DNA in breast milk. Here we describe the case of an HIV-HBV coinfected mother who presents a highly replicative HBV infection postdelivery and showed high level of HBV DNA in breast milk. Despite cumulative exposure to HBV infectious particles during breastfeeding, the child, who had been correctly vaccinated, was not infected by HBV.


hepatitis B virus, HIV, breastmilk, breastfeeding transmission, cumulative exposure

Full Text:

Submitted: 2015-04-12 22:39:40
Published: 2015-07-01 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar


Hepatitis B and breastfeeding. World Health Organization. Journal of the International Association of Physicians in AIDS Care. 1998; 4(7):20-1.

Shi, Z., Yang, Y., Wang, H., Ma, L., Schreiber, A., Li, X., Sun, W., Zhao, X., Yang, X., Zhang, L., Lu, W., Teng, J. & An, Y. Breastfeeding of newborns by mothers carrying hepatitis B virus: a meta-analysis and systematic review. Arch Pediatr Adolesc Med. 2011; 165(9):837-46.

Zheng, Y., Lu, Y., Ye, Q., Xia, Y., Zhou, Y., Yao, Q. & Wei, S. Should chronic hepatitis B mothers breastfeed? a meta analysis. BMC public health. 2011; 11:502.

de Vincenzi I. Triple antiretroviral compared with zidovudine and single-dose nevirapine prophylaxis during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV-1 (Kesho Bora study): a randomised controlled trial. The Lancet infectious diseases. 2011; 11(3):171-80.

Lin HH, Hsu HY, Chang MH, Chen PJ, Chen DS. Hepatitis B virus in the colostra of HBeAg-positive carrier mothers. Journal of pediatric gastroenterology and nutrition. 1993; 17(2):207-10.

de Oliveira PR, Yamamoto AY, de Souza CB, de Araujo, N. M., de Andrade Gomes, S., Heck, A. R., de Castro Figueiredo, J. F. & Mussi-Pinhata, M. M. Hepatitis B viral markers in banked human milk before and after Holder pasteurization. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2009; 45(4):281-4.

Pirillo MF, Scarcella P, Andreotti M, Jere, H., Buonomo, E., Sagno, J. B., Amici, R., Mancini, M. G., Leone, P., Ceffa, S., Mancinelli, S., Marazzi, M. C., Vella, S., Palombi, L. & Giuliano, M. Hepatitis B virus mother-to-child transmission among HIV-infected women receiving lamivudine-containing antiretroviral regimens during pregnancy and breastfeeding. Journal of viral hepatitis. 2015; 22(3):289-96.

ter Borg MJ, Leemans WF, de Man RA, Janssen HL. Exacerbation of chronic hepatitis B infection after delivery. Journal of viral hepatitis. 2008; 15(1):37-41.

Abstract views:


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185     •     Privacy