Original Articles
Vol. 8 (2016): Review, Original Articles, Case Reports
DETECTION OF OCCULT GLOMERULAR DYSFUNCTION IN GLUCOSE SIX PHOSPHATE DEHYDROGENASE DEFICIENCY ANEMIA
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: May 17, 2016
Accepted: July 4, 2016
Accepted: July 4, 2016
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Background:
Glucose six phosphate dehydrogenase deficiency (G6PD) anemia is associated with intravascular hemolysis. The freely filtered hemoglobin can damage the kidney. We aimed to assess gloumerular status in G6PD children.
Methods:
Sixty children were included. Thirty G6PD deficiency anemia children were enrolled during the acute hemolytic crisis and after hemolytic episode. Another thirty healthy children were included as controls. Serum cystatin C, creatinine levels and urinary albumin/creatinine (A/C) ratio were measured for glomerular filtration rate (GFR) calculation.
Results:
Significantly higher urinary A/C ratio and lower GFR were found during hemolysis and after the hemolytic episode compared to controls. Also, significant higher serum cystatin C, creatinine and A/C ratio and lower GFR during acute hemolytic crisis compared to the same children after the hemolytic episode subsided.
Conclusions:
G6PD deficiency anemia is associated with a variable degree of glomerular dysfunction during acute hemolytic episodes. This glomerular dysfunction can result in chronic subclinical or occult chronic kidney injury.
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“DETECTION OF OCCULT GLOMERULAR DYSFUNCTION IN GLUCOSE SIX PHOSPHATE DEHYDROGENASE DEFICIENCY ANEMIA” (2016) Mediterranean Journal of Hematology and Infectious Diseases, 8, p. e2016038. doi:10.4084/mjhid.2016.038.
