Human T-cell leukemia virus type І associated with an increased risk of primary malignant neoplasm

Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura
  • Shinya Fujita
    Kansai Medical University, Japan
  • Atsushi Satake
    Kansai Medical University,
  • Takahisa Nakanishi
    Kansai Medical University, Japan
  • Yoshiko Azuma
    Kansai Medical University,
  • Yukie Tsubokura
    Kansai Medical University,
  • Akiko Konishi
    Kansai Medical University, Japan
  • Masaaki Hotta
    Kansai Medical University, Japan
  • Hideaki Yoshimura
    Kansai Medical University,
  • Kazuyoshi Ishii
    Kansai Medical University, Japan
  • Tomoki Ito
    Kansai Medical University, Japan
  • Shosaku Nomura
    Kansai Medical University, Japan

Abstract

The correlation between human T-cell leukemia virus type І (HTLV-І) infection and malignant neoplasms other than adult T-cell lymphoma (ATL) remains unknown. We analyzed the frequency of primary malignant neoplasm in HTLV-І-seropositive patients. From January 2006 to December 2016, 203 patients were diagnosed as HTLV-І-seropositive at Kansai Medical University Hospital. Among them, 32 developed a primary malignant neoplasm. Their median age was 64 years old, 63% of them were male, and 69% of them were HTLV-I carriers. This group had the following distribution of ATL subtypes: 31% smoldering type, 0% chronic type, 3% acute type, and 3% lymphoma type. Among them, 53% was hematology malignancy, and solid tumor was 47%. The most frequent type of hematological malignancy was T-cell lymphoma (23%), followed B-cell lymphoma (16%), and myelodysplastic syndromes (6%). The most frequent primary solid tumor locations were the lung (15%), followed by the colon (9%), prostate (6%), kidney (6%), cervix (2%), breast (2%), liver (2%), pancreas (2%), and oral cavity (2%). Our results suggest that HTLV-Іinfection is often associated with the development of other malignant neoplasms. Therefore, HTLV-І-positive patients should be made aware of their increased risk for the onset of a malignant neoplasm and undergo increased surveillance.

Keywords

human T-cell leukemia virus type І (HTLV-І), adult T-cell lymphoma (ATL), primary malignant neoplasm, regulatory T-cell(Treg)

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References

Asou N, Kumagai T, Uekihara S, Ishii M, Sato M, Sakai K, Nishimura H, Yamaguchi K, Takatsuki K. HTLV-I seroprevalence in patients with malignancy. Cancer. 1986; 58(4):903-907.

Imamura N, Inada T, Tagaya Y, Yodoi J, Kuramoto A. Socinski MA, Bondarenko I, Karaseva NA, et al. Association between ATL and non-hematopoietic neoplasms. Hematol Oncol. 1993 ;11(3):127-137.

Kozuru M, Uike N, Muta K, Goto T, Suehiro Y, Nagano M. High occurrence of primary malignant neoplasms in patients with adult T-cell leukemia/lymphoma, their siblings, and their mothers. Cancer. 1996 ;78(5):1119-1124.

Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br J Haematol. 1991; 79(3):428-437.

Suefuji H, Ohshima K, Hayabuchi N, Nakamura K, Kikuchi M. HTLV-1 carriers with B-cell lymphoma of localized stage head and neck: prognosis, clinical and immunopathological features. Br J Haematol. 2003; 123(4):606-612.

Beltran BE, Quiñones P, Morales D, Revilla JC, Alva JC, Castillo JJ. Diffuse large B-cell lymphoma in human T-lymphotropic virus type 1 carriers. Leuk Res Treatment. 2012; 2012:262363.

http://www.mc.pref.osaka.jp/ocr/en/index.html [accessed Jan 24, 2018]

Kannagi M, Matsushita S, Shida H, Harada S. Cytotoxic T cell response and expression of the target antigen in HTLV-I infection. Leukemia. 1994; 8 Suppl 1:S54-59.

Ogura M, Ishida T, Tsukasaki K, Takahashi T, Utsunomiya A. Effects of first-line chemotherapy on natural killer cells in adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. Cancer Chemother Pharmacol. 2016; 78(1):199-207.

Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Kawano R, Suzumiya J, Utsunomiya A, Harada M, Kikuchi M. Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br J Haematol. 2004; 126(1):81-84.

Matsubara Y, Hori T, Morita R, Sakaguchi S, Uchiyama T. Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cells. Leukemia. 2005; 19(3):482-483.

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