Human T-cell leukemia virus type І associated with an increased risk of primary malignant neoplasm

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Aya Nakaya *
Shinya Fujita
Atsushi Satake
Takahisa Nakanishi
Yoshiko Azuma
Yukie Tsubokura
Akiko Konishi
Masaaki Hotta
Hideaki Yoshimura
Kazuyoshi Ishii
Tomoki Ito
Shosaku Nomura
(*) Corresponding Author:
Aya Nakaya | nakaya1016@yahoo.co.jp

Abstract

The correlation between human T-cell leukemia virus type І (HTLV-І) infection and malignant neoplasms other than adult T-cell lymphoma (ATL) remains unknown. We analyzed the frequency of primary malignant neoplasm in HTLV-І-seropositive patients. From January 2006 to December 2016, 203 patients were diagnosed as HTLV-І-seropositive at Kansai Medical University Hospital. Among them, 32 developed a primary malignant neoplasm. Their median age was 64 years old, 63% of them were male, and 69% of them were HTLV-I carriers. This group had the following distribution of ATL subtypes: 31% smoldering type, 0% chronic type, 3% acute type, and 3% lymphoma type. Among them, 53% was hematology malignancy, and solid tumor was 47%. The most frequent type of hematological malignancy was T-cell lymphoma (23%), followed B-cell lymphoma (16%), and myelodysplastic syndromes (6%). The most frequent primary solid tumor locations were the lung (15%), followed by the colon (9%), prostate (6%), kidney (6%), cervix (2%), breast (2%), liver (2%), pancreas (2%), and oral cavity (2%). Our results suggest that HTLV-Іinfection is often associated with the development of other malignant neoplasms. Therefore, HTLV-І-positive patients should be made aware of their increased risk for the onset of a malignant neoplasm and undergo increased surveillance.


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Author Biographies

Aya Nakaya, Kansai Medical University

First Department of Internal Medicine

Shinya Fujita, Kansai Medical University

First Department of Internal Medicine

Atsushi Satake, Kansai Medical University

First Department of Internal Medicine

Takahisa Nakanishi, Kansai Medical University

First Department of Internal Medicine

Yoshiko Azuma, Kansai Medical University

First Department of Internal Medicine

Yukie Tsubokura, Kansai Medical University

First Department of Internal Medicine

Akiko Konishi, Kansai Medical University

First Department of Internal Medicine

Masaaki Hotta, Kansai Medical University

First Department of Internal Medicine

Hideaki Yoshimura, Kansai Medical University

First Department of Internal Medicine

Kazuyoshi Ishii, Kansai Medical University

First Department of Internal Medicine

Tomoki Ito, Kansai Medical University

First Department of Internal Medicine

Shosaku Nomura, Kansai Medical University

First Department of Internal Medicine

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