LABORATORY BIOMARKERS TO FACILITATE DIFFERENTIAL DIAGNOSIS BETWEEN MEASLES AND KAWASAKI DISEASE IN A PEDIATRIC EMERGENCY ROOM: A RETROSPECTIVE STUDY

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Danilo Buonsenso *
Giulia Macchiarulo
Maria Chiara Supino
Francesco La Penna
Simona Scateni
Alessandra Marchesi
Antonino Reale
Elena Boccuzzi
(*) Corresponding Author:
Danilo Buonsenso | danilobuonsenso@gmail.com

Abstract

This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in a emergency room. We found similar clinical features as duration of fever and number of KD criteria (p >0.5) but significant differences in white blood cell count, neutrophils, CRP and LDH levels (p < 0.001). LDH value ≥ 800 mg/dl had sensibility of 89% and specificity of 90% for Measles while CRP ≥ 3 mg/dl had sensibility 89% and specificity of 85% for KD. The combined use of CRP, LDH and AST showed accuracy of 86.67%.


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Author Biographies

Danilo Buonsenso, Danilo Buonsenso, MD, Catholic University of Sacred Heart—A. Gemelli Hospital, Department of Pediatrics, Pediatric Infectious Disease Unit, Largo A. Gemelli 8, 00168 Rome, Italy. E-mail:

nothing to declare

Maria Chiara Supino

Francesco La Penna1, Simona Scateni1, Alessandra Marchesi5, Antonino Reale1, Elena Boccuzzi1

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