Megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver

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Alessandro Malara
Vittorio Abbonante
Maria Zingariello
Anna Rita Franco Migliaccio
Alessandra Balduini *
(*) Corresponding Author:
Alessandra Balduini | alessandra.balduini@unipv.it

Abstract

In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis. Additionally, we describe recent evidences showing that the role of megakaryocytes in tissue fibrosis is not limited to the bone marrow.

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Author Biographies

Alessandro Malara, University of Pavia

Department of MOlecular Medicine

Vittorio Abbonante, University of Pavia

Department of Molecular Medicine

Maria Zingariello, University Campus Bio-Medico, Rome

Unit of Microscopic and Ultrastructural Anatomy, Dept of Medicine

Anna Rita Franco Migliaccio, Alma Mater University, Bologna

Department of Biomedical and Neuromotorial Sciences

Alessandra Balduini, University of Pavia

DEpartment of Molecular Medicine