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issue of iron overload in hemopoietic cell transplantation has been
first discussed in the field of transplantation for thalassemia.
Thalassemia major is characterized by ineffective erythropoiesis and
hemolysis leading to severe anemia. Patients require regular blood
transfusion therefore they develop iron overload causing organ damage
and hematopoietic cell transplantation (HCT) is a consolidated
reliably curative option.
Recently Understood Mechanisms Support Iron Toxicity and Cell Damage
Iron in Phisiological and Pathological Conditions
|Table 1. Free iron forms types and property.|
Free Iron Toxicity before Transplant
Free Iron Toxicity During the Engraftment Period
Free Iron Toxicity During the Early Transplant Phase (Before a Sustained Engraftment is Achieved)
Iron Chelation Therapy after Transplant in TDT