THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES

Main Article Content

Giovanni Roti
Claudia Sorrentino
Antonio Cuneo

Keywords

NOTCH1, Targeted therapy, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma

Abstract

The Notch pathway plays a key role in several processes including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable target in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients’ outcome. In this brief review, we outline the therapeutic potential of targeting Notch pathway in T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia and mantle cell lymphoma.

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References

We would recommend these colleagues as potential referees:

Prof. Cristina Mecucci, M.D.; Ph.D.
University of Perugia
cristina.mecucci@unipg.it

Dr. Sabina Chiaretti
University “La Sapienza” of Roma
chiaretti@bce.uniroma1.it