and Clinical Immunology Unit, Department of Medicine, University of
Padua School of Medicine, Padova, Italy.
2 Department of Laboratory Medicine, Department of Medicine, University of Padua School of Medicine, Padova, Italy.
| This is an Open Access article distributed
under the terms of the Creative Commons Attribution License
(https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
infections represent life-threatening complications in patients with
febrile neutropenia (FN). Diagnostic biomarkers of infections may help
to differentiate bacteraemia from non-bacteraemia FN. We aimed to
evaluate the utility of procalcitonin (PCT), presepsin (PS), C-reactive
protein (CRP) and interleukin-8 (IL-8) as biomarkers of bacteraemia in
adult FN patients with haematological malignancies.
Methods and Patients
|Figure 1. Flow chart showing the selection of patients for inclusion in the study|
|Table 1. Characteristics of patients according to FN subtypes.|
|Figure 2. PCT, CRP, PS and IL-8 levels in neutropenic subjects. All markers were measured at 12-24 hours from febrile neutropenia onset. Median concentration of PCT (a), CRP (b), PS (c) and IL-8 (d) and interquartile ranges in each group are shown. Probability: * p < 0.05 and ** p < 0.01|
|Table 2. CRP, IL-8, PCT, and PS levels in neutropenic subjects.|
|Table 3. AUC, cut-off, sensibility, specificity, positive predictive value (PPV) and negative predictive value (NPV) for variables predicting bacteraemia.|