of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong
University, No. 27 Shanda South Road, Jinan, Shandong, 250012, China.
2 Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
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(https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Donor natural killer (NK) cell alloreactivity in umbilical cord bone
marrow transplantation (UCBT) can lead to leukemic relapse. However, NK
cell function is calibrated by interaction with human leukocyte
antigens (HLAs). This study aimed to investigate graft-resistant
leukemia after transplantation and compared specific genotypes of
killer immunoglobulin-like receptors (KIRs) in donors and human
leukocyte antigen ligands in patients.
Materials and Methods
|Table 1. Patients’ characteristics for the three groups according to HLA-B subtype.
2. Transplantation results of the three groups according to HLA-B subtype.
|Figure 1. DFS of the three groups after UCBT. DFS in the Bw4-80I group was significantly higher than that in the Bw6 group.|
|Figure 2. OS after UCBT. The Bw6 group appeared to have worse OS than the other two groups, but this was not significant.|