“Hemolysis, or not Hemolysis, that is the question”. Use of hydroxychloroquine in a patient with COVID-19 infection and G6PD deficiency. Hemolysis by Hemolysis and G6PD deficiency.

Main Article Content

Lidia Dalfino
Antonio Palma
Angelantonio Vitucci
Daniela Campanale
Salvatore Grasso
Pellegrino Musto



Download data is not yet available.
Abstract 663 | PDF Downloads 471 HTML Downloads 128


Costanzo M, De Giglio MAR, Roviello GN. SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus. Curr Med Chem. 2020;27(27):4536-4541. https://doi.org/10.2174/0929867327666200416131117 PMid:32297571
2. ISS COVID-19 Rare Diseases Working Group. Interim guidance for the appropriate support of people with enzymopenia G6PD (favism) in the current SARS-CoV-2 emergency scenario. Version April 14, 2020. Roma: Istituto Superiore di Sanità; 2020. (Rapporto ISS COVID-19, n. 14/2020 - English version).
3. Beauverd Y, Adam Y, Assouline B, Samii K. COVID-19 infection and treatment with hydroxychloroquine cause severe haemolysis crisis in a patient with glucose-6-phosphate dehydrogenase deficiency [published online ahead of print, 2020 Apr 23]. Eur J Haematol. 2020;10.1111/ejh.13432. https://doi.org/10.1111/ejh.13432 PMid:32324284 PMCid:PMC7264743
4. Maillart E, Leemans S, Van Noten H, et al. A case report of serious haemolysis in a glucose-6-phosphate dehydrogenase-deficient COVID-19 patient receiving hydroxychloroquine. Infect Dis (Lond). 2020;52(9):659-661.
https://doi.org/10.1080/23744235.2020.1774644 PMid:32496938 PMCid:PMC7284136
5. Sasi S, Yassin MA, Nair AP, Al Maslamani MS. A Case of COVID-19 in a Patient with Asymptomatic Hemoglobin D Thalassemia and Glucose-6-Phosphate Dehydrogenase Deficiency. Am J Case Rep. 2020;21:e925788. Published 2020 Jul 22.
https://doi.org/10.12659/AJCR.925788 PMid:32697769 PMCid:PMC7394553
6. De Franceschi L, Costa E, Dima F, Morandi M, Olivieri O. Acute hemolysis by hydroxycloroquine was observed in G6PD-deficient patient with severe COVD-19 related lung injury. Eur J Intern Med. 2020;77:136-137. https://doi.org/10.1016/j.ejim.2020.04.020 PMid:32381323 PMCid:PMC7167571
7. Roper D, Layton M, Rees D, et al. Laboratory diagnosis of G6PD deficiency. A British Society for Haematology Guideline. Br J Haematol. 2020;189(1):24-38.https://doi.org/10.1111/bjh.16366; PMid:31991476
8. Pietrapertosa A, Palma A, Campanale D, Delios G, Vitucci A, Tannoia N. Genotype and phenotype correlation in glucose-6-phosphate dehydrogenase deficiency. Haematologica. 2001;86(1):30-35.
9. Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;371(9606):64-74.
10. Kassi EN, Papavassiliou KA, Papavassiliou AG. G6PD and chloroquine: Selecting the treatment against SARS-CoV-2?. J Cell Mol Med. 2020;24(9):4913-4914. https://doi.org/10.1111/jcmm.15312 PMid:32281268 PMCid:PMC7205832

Most read articles by the same author(s)