of Infectious Diseases, The First-affiliated Hospital of Hunan Normal
University (Hunan Provincial People's Hospital), Changsha, 410005,
2 School of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
3 Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, The First-affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, Hunan, China.
4 The Fourth People's Hospital of Yiyang, Yiyang, 413000, Hunan, China.
5 Department of Pediatrics, Yiyang Central Hospital, Yiyang, Hunan 413099, P.R. China.
6 Department of Geriatrics, The First-affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, Hunan, China.
7 Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, Hunan, China.
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under the terms of the Creative Commons Attribution License
(https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Coronavirus disease 2019 (COVID-19) is highly contagious and deadly and
is associated with coagulopathy. Pentraxin-3(PTX3) participates in
innate resistance to infections and plays a role in thrombogenesis.
Materials and Methods
1. C.T. imaging performance and corresponding score system.
|Table 2. Clinical and laboratory findings in patients with COVID-19.
|Figure 1. Serum PTX3 levels in D-dimer_L (D-dimer＜1mg/L) and D-dimer_H (D-dimer≥1mg/L) groups. (P＜0.001).|
|Figure 2. The relationship between serum PTX3 levels and plasma D-dimer(A), chest CT imaging scores(B) and length of stay(C). There was a positive relationship between PTX3 and D-dimer (r=0.461, P=0.003), chest CT imaging scores(r=0.418, P=0.008) and length of stay(r=0.486, P=0.002).|
|Figure 3. ROC curve for WBC, CRP, ESR, and PTX3 in COVID-19 patients. ROC curve analysis revealed that the AUC of WBC, CRP, ESR, and PTX3 for COVID-19 were 0.685, 0.863, 0.846, and 0.985, respectively.|
|Table 3. Univariate analysis of categorical variables.
|Table 4. Correlation analysis between continuous variables and plasma D-dimer levels
|Table 5. Multiple linear regression analysis of the relationship between laboratory findings and plasma D-dimer levels.