Chiara Agrati1, Veronica Bordoni1, Alessandra Sacchi1, Nicola Petrosillo1, Emanuele Nicastri1, Franca Del Nonno1, Gianpiero D’Offizi1, Fabrizio Palmieri1, Luisa Marchioni1, Maria Rosaria Capobianchi1, Andrea Antinori1, Giuseppe Ippolito1 and Michele Bibas1.
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Coronavirus disease 2019 (COVID-19) is mainly a respiratory tract
disease and acute respiratory failure with diffuse microvascular
pulmonary thrombosis are critical aspects of the morbidity and
mortality of this new syndrome.
|Figure 1. The expression of P-selectin and Annexin V on platelet surface was evaluated in plasma samples by flow cytometry (A). The removal of platelets/vescicles in EV-free plasma samples was confirmed by flow cytometry (B).
Material and Methods
|Figure 2. Clinical features of enrolled COVID-19 patients (A). Soluble P-selectin was quantified in plasma samples (B-C)
and in extracellular-free plasma samples (EV-free, C) from healthy
donors (HD, n=10), ICU (n=27) and in non-ICU (n=19) COVID-19 patients
by ELISA assay. Data were compared by Mann-Whitney test. * p<0.05
was considered significant.