1 Emeritus Director in Pediatrics, Santobono-Pausilipon Children's Hospital, Naples, Italy.
2 Department of Woman, Child, General and Specialized Surgery, University "Luigi Vanvitelli", Naples. Italy.
3 Royal Lancaster Infirmary, Lancaster, Lancashire, United Kingdom.
4 Thalassemia Unit, Nicosia, Cyprus.
5 Medical Student, European University Cyprus, School of Medicine, Nicosia, Cyprus.
6 Pediatric Registrar, Archbishop Makarios III Hospital, Nicosia, Cyprus.
7 Pediatric and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara, Italy.
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Menarche is an important milestone in a feminine reproductive life, and
regular menstrual cycles reflect normal functioning of the
hypothalamic-pituitary-ovarian axis, a vital sign of women's general
Patients and Study Design
1. Correlation between age at start of chelation therapy with DFO (yrs)
and serum ferritin levels at menarche (ng/ml) (n = 79, r = 0,34; p = 0,
1. Ages at menarche (≤ or > 14 yrs) distributed in relation to the age at start of ICT with DFO.
|Figure 2. Correlation between age at menarche (yrs) and BMI-Z score at menarche timing (n = 67, r = - 0,45 ; p = 0,00001).
|Table 2. Prevalence of regular and irregular menstrual cycles in relation to the age at menarche (≤ or > 14 yrs).