of ICET-A Network (International Network of Clinicians for
Endocrinopathies in Thalassemia and Adolescent Medicine) and Pediatric
and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara, Italy.
2 Department of Pediatrics, Division of Endocrinology, Hamad General Hospital, Doha, Qatar and Department of Pediatrics, Division of Endocrinology, Alexandria University Children’s Hospital, Alexandria, Egypt.
3 Department of Diabetes and Endocrinology, Whittington Hospital, University College London, London, UK.
4 Department of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
5 Emeritus Director in Pediatrics, Children’s Hospital “Santobono-Pausilipon”, Naples, Italy.
6 Department of Pediatrics, NYU School of Medicine, New York, NY, USA.
7 First Department of Paediatrics, National Kapodistrian University of Athens 11527, Greece.
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dysregulation (GD), including prediabetes and diabetes mellitus (DM),
is a common complication of transfusion-dependent β-thalassemia (TDT)
patients. The prevalence increases with age and magnitude of iron
overload, affecting a significant proportion of patients. According to
the international guidelines, the development of GD is frequently
asymptomatic. Therefore, an early diagnosis requires an annual oral
glucose tolerance test (OGTT) in all TDT patients aged ten years or
Patients and Methods
1. Clinical and laboratory characteristics of 18 TDT patients with
normal glucose tolerance (NGT) and 10 TDT patients with isolated
impaired fasting glucose (IFG) after OGTT compared to 18 healthy
prepubertal controls. The values are expressed as mean ± SD.
1. Glucose abnormalities, after OGTT, at last observation. Legend: NGT:
normal glucose tolerance; IFG: impaired fasting glucose; IGT: impaired
glucose tolerance; Type 2 DM: type 2 diabetes mellitus.
|Table 2. Clinical and
laboratory characteristics in 12 TDT patients with normal glucose
tolerance (NGT) and glucose dysregulation (GD), after OGTT, at
last observation compared to adult controls. The values are expressed
as mean ± SD.