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against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are
critical weapons to control the spread of the deadly Coronavirus
2019(COVId-19) virus worldwide. Although these vaccines are generally
safe, their widespread use has produced reports of rare complications,
including vaccine-induced immune thrombotic thrombocytopenia (VIITT),
particularly in connection with ChAdOx1 nCov-19. We have identified
three cases of sickle cell disease (SCD) experiencing a severe
vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being
stable for a long time, they had fever with tachycardia, along with a
significant rise in WBC, liver enzymes, particularly alkaline
phosphate, with a remarkable drop in hemoglobin, and platelets and one
of them had probably a fatal TTP like syndrome. Given these findings,
physicians and patients should exercise caution when taking this type
of vaccine and be aware of these safety concerns.
1. Demographic, clinical and laboratory features.