Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T)

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Eugenio Galli
Catholic University of Sacred Heart
http://orcid.org/0000-0002-2839-916X
Silvia Bellesi
Marcello Viscovo
Federica Sorà
Stefan Hohaus
Nicola Piccirillo
Luca Laurenti
Patrizia Chiusolo
Valerio De Stefano
Simona Sica
Gina Zini

Keywords

Chimeric antigen receptor T cells, CAR-T, cytomorphology, immunotherapy, cell therapy

Abstract

Chimeric antigen receptor (CAR) T cells represent one of the newest frontiers of cell therapy. Their application currently involves relapsed/refractory aggressive B cell lymphoma and leukemia as a standard of care, while several studies are exploring CAR-T to treat multiple myeloma and other hematological malignancies. Here we describe the cytomorphology of CAR-T collected from the leftovers of infusion bags, and therefore before the encounter with the antigen, with, among others, a peculiar population of giant lymphoid cells with blastoid features and hypertrophic centrosome.

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References

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Published
Oct 29, 2021
DOI https://doi.org/10.4084/MJHID.2021.066

Article Details

How to Cite

Galli, E. (2021) “Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T)”, Mediterranean Journal of Hematology and Infectious Diseases, 13(1), p. e2021066. doi: 10.4084/MJHID.2021.066.
Issue
Vol. 13 No. 1 (2021): Mediterranean Journal of Hematology and Infectious Diseases, Volume 13, 2021
Section
Scientific Letters
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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