Ming Tong1,2*, Xiquan Yan2,3*, Yu Jiang2*, Zhaoxia Jin4, Shengjiao Zhu5, Lianhong Zou2, Yanjuan Liu2, Qing Zheng6, Guoqiang Chen5, Ruifeng Gu5, Zhilan Zhou5, Xiaotong Han2, Jiangming He7, Siqing Yin8, Changchun Ma9, Wen Xiao2, Yong Zeng10#, Fang Chen2,3# and Yimin Zhu2,3#.
of Infectious Diseases, Hunan Provincial People's Hospital (The
First-affiliated Hospital of Hunan Normal University), Changsha, Hunan,
2 Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
3 School of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
4 Department of Cardiology, Huanggang Central Hospital, Huanggang, Hubei, China.
5 Department of Laboratory Medicine, Huanggang Central Hospital, Huanggang, Hubei, China.
6 Department of Geriatrics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
7 Department of Public Health, Huangzhou General Hospital, Huanggang, Hubei, China.
8 Huangzhou District Maternal and Child Health Hospital, Huanggang, Hubei, China.
9 Department of Neurosurgery, Huangzhou District People's Hospital, Huanggang, Hubei, China.
10 Huanggang Central Hospital, Huanggang, Hubei, China.
*Contributed equally. #Contributed equally.
| This is an Open Access article distributed
under the terms of the Creative Commons Attribution License
(https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
COVID-19 is characterized by endothelial dysfunction and is presumed to
have long-term cardiovascular sequelae. In this cross-sectional study,
we aimed to explore the serum levels of endothelial biomarkers in
patients who recovered from COVID-19 one year after hospital discharge.
|Figure 1. Flow chart of patients with COVID-19 discharged from Huanggang Hospitals between January 24 to March 18, 2020.
#A self-reported symptom questionnaire included Low-grade fever, Fatigue or muscle weakness, Palpitations, Chest tightness or shortness of breath, Dizziness. *Laboratory tests included routine blood tests, biochemical and immunologic tests, the plasma levels of CRP, IL-6, and D-dimer, and the serum levels of VCAM-1, ICAM-1, P-Selectin and fractalkine.
Abbreviations: ACEIs: angiotensin-converting enzyme inhibitors; ARBs: angiotensin II type-1 receptor antagonists.
|Table 1. Demographics and laboratory findings of participants.|
|Table 2. Symptoms, electrocardiogram manifestations and lower extremities Doppler ultrasound of recovers.|
|Figure 2. Serum levels of vascular cell adhesion molecule-1(VCAM-1), intercellular cell adhesion molecule-1(ICAM-1), P-selectin, and fractalkine in controls and COVID-19 recovers of previously mild or severe infected.|