THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES Role of white blood cell count in perianal pathologies

Main Article Content

Bedrettin Orhan
Fahir Özkalemkaş https://orcid.org/0000-0001-9710-134X
Vildan Özkocaman https://orcid.org/0000-0003-0014-7398
Büşra Gürbüz https://orcid.org/0000-0002-5564-8862
Tuba Ersal https://orcid.org/0000-0001-5419-3221
İbrahim Ethem Pınar https://orcid.org/0000-0001-9907-1498
Cumali Yalçın https://orcid.org/0000-0002-5129-2977
Ömer Candar https://orcid.org/0000-0001-7602-6926
Sinem Çubukçu https://orcid.org/0000-0001-9623-8096
Tuba Güllü Koca https://orcid.org/0000-0003-4168-2821
Rıdvan Ali https://orcid.org/0000-0001-6486-3399

Keywords

Perianal, acute leukemia, white blood cell

Abstract

Background and Objective: Perianal pathologies are the most common cause of perianal infections in patients with hematological malignancies. Perianal infection diagnosis in this group of patients is difficult, thus careful anorectal examination is necessary, with imaging modalities. The literature revealed a knowledge gap on the approach of anal pathologies in patients with neutropenia during diagnosis or chemotherapy. This study aimed to examine our institutional data of perianal complications and investigate the relationship among the white blood cell-neutrophil count, perianal lesion, and the type of treatment in patients with hematologic malignancies during the neutropenic period.


Methods: Patients with a hematologic malignancy, hospitalized for cytotoxic chemotherapy, complicated by perianal pathology, and documented by at least one imaging method were included in the study.


Results: A total of 42 patients were included in the study. The comparison between the groups revealed no statistical significance between the anal abscess formation and the neutrophil count and previous perianal pathology. A statistical significance in favor of acute myeloid leukemia was found between patient diagnosis and anal abscess development. An inverse relationship was found between the number of white blood cells at hospitalization and having an anal pathology operation. It was observed that patients with high white blood cell count were less operated on due to anal pathology.


Conclusions: In conclusion, this article has shown that white blood cell count at the time of hospitalization in patients with hematological malignancy, can affect the operation status of patients due to anal pathologies that may occur in the neutropenic period.

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References

1. Chen CY, Cheng A, Huang SY, Sheng WH, Liu JH, Ko BS, Yao M, Chou WC, Lin HC, Chen YC, Tsay W, Tang JL, Chang SC, Tien HF. Clinical and microbiological characteristics of perianal infections in adult patients with acute leukemia. PLoS One. 2013;8(4):e60624.
2. Büyükaşik Y, Ozcebe OI, Sayinalp N, Haznedaroğlu IC, Altundağ OO, Ozdemir O, Dündar S. Perianal infections in patients with leukemia: importance of the course of neutrophil count. Dis Colon Rectum. 1998;41(1):81-5.
3. Haliloglu N, Gulpinar B, Ozkavukcu E, Erden A. Typical MR imaging findings of perianal infections in patients with hematologic malignancies. Eur J Radiol. 2017;93:284-8.
4. Loureiro RV, Borges VP, Tomé AL, Bernardes CF, Silva MJ, Bettencourt MJ. Anorectal complications in patients with haematological malignancies. Eur J Gastroenterol Hepatol. 2018;30(7):722-6.
5. Schimpff SC, Wiernik PH, Block JB. Rectal abscesses in cancer patients. Lancet. 1972;2(7782):844-7.
6. Badgwell BD, Chang GJ, Rodriguez-Bigas MA, Smith K, Lupo PJ, Frankowski RF, Delclos G, Du XL, Cormier J. Management and outcomes of anorectal infection in the cancer patient. Ann Surg Oncol. 2009;16(10):2752-8.
7. Baker B, Al-Salman M, Daoud F. Management of acute perianal sepsis in neutropenic patients with hematological malignancy. Tech Coloproctol. 2014;18(4):327-33.
8. Morcos B, Amarin R, Abu Sba A, Al-Ramahi R, Abu Alrub Z, Salhab M. Contemporary management of perianal conditions in febrile neutropenic patients. Eur J Surg Oncol. 2013;39(4):404-7.
9. Solmaz S, Korur A, Gereklioğlu Ç, Asma S, Büyükkurt N, Kasar M, Yeral M, Kozanoğlu İ, Boğa C, Ozdoğu H. Anorectal Complications During Neutropenic Period in Patients with Hematologic Diseases. Mediterr J Hematol Infect Dis. 2016;8(1):e2016019.
10. Lehrnbecher T, Marshall D, Gao C, Chanock SJ. A second look at anorectal infections in cancer patients in a large cancer institute: the success of early intervention with antibiotics and surgery. Infection. 2002;30(5):272-6.
11. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10-29.
12. Chang H, Kuo MC, Tang TC, Lin TL, Wu JH, Hung YS, Wang PN. Clinical Features and Recurrence Pattern of Perianal Abscess in Patients with Acute Myeloid Leukemia. Acta Haematol. 2017;138(1):10-3.
13. Camera A, Andretta C, Villa MR, Volpicelli M, Picardi M, Rossi M, Rinaldi CR, Della Cioppa P, Ciancia R, Selleri C, Rotoli B. Intestinal toxicity during induction chemotherapy with cytarabine-based regimens in adult acute myeloid leukemia. Hematol J. 2003;4(5):346-50.