Acquired Sideroblastic Anemia: An exploratory Comparative Statistical Analysis Between Clonal and Non-clonal cases Acquired Sideroblastic Anemia
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Key words: sideroblastic anemia, copper deficiency, non-clonal sideroblastic anemia
Abstract
Sideroblastic anemia (SA) is a rare heterogenous group of inherited and acquired bone marrow disorders. We retrospectively studied the clinicopathologic characteristics, cytogenetic findings, and disease outcome of patients with acquired sideroblastic anemia (ASA) and performed a comparative analysis between clonal and non-clonal cases. 15 patients of ASA were detected: clonal SA (10 cases, 66.7%) including MDS, MDS/MPN, AML and t-MNs with ring sideroblasts) and SA secondary to non-clonal causes (5 cases; 33.3%), including copper deficiency (2 sideroblastic anemia, copper deficiency, non-clonal sideroblastic anemia cases), pyridoxine deficiency diagnosed during pregnancy, and 2 patients with idiopathic SA.Key
Keywords: sideroblastic anemia, copper deficiency, non-clonal sideroblastic anemia
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References
2. Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405.
3. Mufti GJ, Bennett JM, Goasguen J, Bain BJ, Baumann I, Brunning R, et al. Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts. Haematologica. 2008;93(11):1712-7.
4. Brissot P, Bernard DG, Brissot E, Loréal O, Troadec MB. Rare anemias due to genetic iron metabolism defects. Mutat Res Rev Mutat Res. 2018 Jul - Sep; 777:52-63.
5. Papaemmanuil E, Gazzola M, Boultwood J, et al. (2011). Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 365:1 384- 95. PMID:21995386
6. Abu-Zeinah G, DeSancho MT. Understanding Sideroblastic Anemia: An Overview of Genetics, Epidemiology, Pathophysiology and Current Therapeutic Options. J Blood Med. 2020 Sep 25;11:305-318.
7. Alcindor T, Bridges KR (2002). Sideroblastic anaemias. Br J Haematol. 116:733-43. PMID:11886376
8. Ohba R, Furuyama K, Yoshida K, et al. Clinical and genetic characteristics of congenital sideroblastic anemia: comparison with myelodysplastic syndrome with ring sideroblast (MDS-RS). Ann Hematol. 2013. 92:1-9. PMID:22983749
9. Wazir SM, Ghobrial I. Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy. J Community Hosp Intern Med Perspect. 2017;7:265–8.
10. López Melero E, Ruíz-Roso G, Botella I, Ortego Pérez S, Delgado M, Fernández Lucas M. Pancytopenia due to copper deficiency in a hemodialysis patient. Nefrología.
11. Marumo A, Yamamura T, Mizuki T, Tanosaki S, Suzuki K. Copper deficiency induced pancytopenia after taking an excessive amount of zinc formulation during maintenance hemodialysis. J Res Med Sci 2021;26:42.2019;39:451–452.
12. Konopka L, Hoffbrand AV. Haem synthesis in sideroblastic anaemia. Br J Haematol. 1979;42(1):73–83. doi:10.1111/j.1365-2141.1979. tb 03699.x
13. Fei Wang, Geng Wang; Transient appearance of ring sideroblasts in peripheral blood in the acute phase of secondary hemolytic anemia. Blood 2019; 133 (9): 1000. Doi
14. Martin-Cabrera P, Jeromin S, Perglerovà K, Haferlach C, Kern W, Haferlach T. Acute myeloid leukemias with ring sideroblasts show a unique molecular signature straddling secondary acute myeloid leukemia and de novo acute myeloid leukemia. Haematologica. 2017;102(4):e125-e128. doi:10.3324/haematol.2016.156844
15. Kohla S, Ali E, Amer A, Yousif T, Yassin MA. A Rare Case of Severe Copper Deficiency in an Infant with Exclusive Breast Feeding Mimicking Myelodysplastic Syndrome. Case Rep Oncol. 2020 Feb 4;13(1):62-68. doi: 10.1159/000505483.
16. Shehab Fareed, Firyal Ibrahim, Mohamad Najib Alasafar, et al. Recurrent sideroblastic anaemia during pregnancy. Authorea. May 09, 2022 [ preprint].
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