Gamma heavy chain disease associated with T-cell large granular lymphocyte lymphoproliferative disorder: case report and literature review.

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Maria Laura Bisegna
Maria Assunta Limongiello
Stefano Fiori
Maria Stefania De Propris
Irene Della Starza
Stefania Trasarti

Keywords

gamma heavy-chain disease, lymphoproliferative disorders, plasma cell, electrophoresis

Abstract

Heavy chain diseases are rare B-cell neoplasms consisting of the production of a monoclonal immunoglobulin composed of the only heavy chain without corresponding light chains. It is a rare adult disease that may involve several sites with a variable clinical course. It manifests itself on a large spectrum from indolent to rapidly progressive. We present a case of heavy chain disease and concomitant T- cell large granular lymphoproliferative disorder, an association described in only six cases before. 

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