Luca Guarnera1, Gentiana Elena Trotta1, Valentina Boldrini1, Lucia Cardillo1, Ilaria Cerroni1, Valeria Mezzanotte1, Gianmario Pasqualone1, Arianna Savi1, Beatrice Borsellino1, Elisa Buzzatti1, Raffaele Palmieri1, Giovangiacinto Paterno1, Luca Maurillo1, Francesco Buccisano1, Adriano Venditti1 and Maria Ilaria Del Principe1.
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Colonization by multidrug-resistant organisms (MDRO) is a frequent
complication in hematologic departments, which puts patients at risk of
life-threatening bacterial sepsis. Fever of unknown origin (FUO) is a
condition related to the delivery of chemotherapy in hematologic
malignancies, in which the use of antibiotics is debated. The
incidence, risk factors, and influence on the outcome of these
conditions in patients with acute myeloid leukemia (AML) are not
Material and Methods
|Table 1. Characteristics of study population.|
|Table 2. AML therapeutic regimens.
|Figure 1. MDRO detected
in the study population. Abbreviations: CRE, carbapenem-resistant
Enterobacteriaceae; ESBL, extended-spectrum beta-lactamases; MRSA,
methicillin-resistant staphylococcus aureus; VRE, vancomycin-resistant
|Figure 2. 60 days survival function in MDRO study population; comparison between patients who presented FUO and those who didn’t.|
|Figure 3. Correlations between FUO, BSI and MDRO colonization. The "+" sign refers to the occurrence of the FUO and/or BSI event; the "-" sign refers to the non-occurrence of the event. In some long admissions, both events occurred (Columns in front).|
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