@article{Guarnera_Boldrini_Pasqualone_Cimino_Meddi_Laureana_Trivigno_Del Poeta_Mauriello_Anemona_et al._2022, title={Coexistence of T-Large Granular Lymphocyte Leukemia and Peripheral T Cell Lymphoma-NOS with indolent behaviour}, volume={14}, url={https://www.mjhid.org/mjhid/article/view/4753}, DOI={10.4084/MJHID.2022.006}, abstractNote={<p>T-cell lymphomas and leukemias are highly heterogeneous groups of rare disorders. We report a case of a 68-year-old man patient who develops two different T-cell neoplasms (Large Granular Lymphocyte Leukemia [LGLL] in 2018 and Peripheral T-cell non-Hodgkin lymphoma  not otherwise specified [PTCL-NOS] in 2019) with a previous diagnosis of B-cell marginal zone lymphoma in 2010, treated with two lines of chemo-immunotherapy. The coexistence of these different T-cell neoplasms is rarely reported in literature and, moreover, is usually described as an LGLL transformation into PTCL-NOS; differently from these examples, herein the simultaneous conditions appear to be driven by different T-cell clones. Furthermore, the PTCL-NOS had a quite unusual behaviour, with a good disease control without intensive treatment. Because of these features, it could belong to a subgroup of indolent PTCL-NOS, not yet described in the WHO classification of T-cell neoplasms, which could benefit of less aggressive treatment.</p>}, number={1}, journal={Mediterranean Journal of Hematology and Infectious Diseases}, author={Guarnera, Luca and Boldrini, Valentina and Pasqualone, Gianmario and Cimino, Carolina and Meddi, Elisa and Laureana, Roberta and Trivigno, Donata and Del Poeta, Giovanni and Mauriello, Alessandro and Anemona, Lucia and et al.}, year={2022}, month={Jan.}, pages={e2022006} }