TY - JOUR AU - Spinelli, Orietta AU - Tosi, Manuela AU - Peruta, Barbara AU - Guinea Montalvo, Marie Lorena AU - Maino, Elena AU - Scattolin, Anna Maria AU - Parolini, Margherita AU - Viero, Piera AU - Rambaldi, Alessandro AU - Bassan, Renato PY - 2014/08/28 Y2 - 2024/03/29 TI - PROGNOSTIC SIGNIFICANCE AND TREATMENT IMPLICATIONS OF MINIMAL RESIDUAL DISEASE STUDIES IN PHILADELPHIA-NEGATIVE ADULT ACUTE LYMPHOBLASTIC LEUKEMIA JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 6 IS - 1 SE - Review Articles DO - 10.4084/mjhid.2014.062 UR - https://www.mjhid.org/mjhid/article/view/2014.062 SP - e2014062 AB - <p>Acute lymphoblastic leukemia (ALL) is curable in about 40-50% of adult patients, however this is subject to ample variations owing to several host- and disease-related prognostic characteristics. Currently, the study of minimal residual disease (MRD) following induction and early consolidation therapy stands out as the most sensitive individual prognostic marker to define the risk of relapse following the achievement of remission, and ultimately that of treatment failure or success. Because substantial therapeutic advancement is now being achieved using intensified pediatric-type regimens, MRD analysis is especially useful to orientate stem cell transplantation choices. These strategic innovations are progressively leading to greater than 50% cure rates. </p> ER -