TY - JOUR AU - Kostic, Irena AU - Gurrieri, Carmela AU - Piva, Elisa AU - Semenzato, Gianpietro AU - Plebani, Mario AU - Caputo, Ilaria AU - Vianello, Fabrizio PY - 2019/08/29 Y2 - 2024/03/29 TI - COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 11 IS - 1 SE - Original Articles DO - 10.4084/mjhid.2019.047 UR - https://www.mjhid.org/mjhid/article/view/2019.047 SP - e2019047 AB - <p>Bacterial infections represent life-threatening complications in patients with febrile neutropenia (FN). Biomarkers of infections may help to differentiate bacteraemia from non-bacteraemia FN. We aimed to evaluate the utility of procalcitonin (PCT), presepsin (PS), C-reactive protein (CRP) and interleukin-8 (IL-8) as biomarkers of bacteraemia in adult FN patients with haematological malignancies.&nbsp;Thirty-six FN episodes experienced by 28 oncohematological patients were considered.&nbsp;11 out of 36 episodes were classified as bacteraemia. PCT was the best biomarker to predict bacteraemia with area under the curve (AUC) ROC of 0,9; while the most sensitive was IL-8 (90,9%) with AUC ROC of 0,88. All patients with PCT concentrations above 1,6 ?g/l had bacteraemia. Patients with IL-8 concentrations &gt; 170 pg/ml or&nbsp;PS concentrations superior then 410 pg/ml had 40 times and 24 times higher risk for bacteraemia, respectively. PCT remains better than IL-8 and PS in predicting bacteraemia in adult hematological patients with FN.</p> ER -