TY - JOUR AU - Guarnera, Luca AU - Boldrini, Valentina AU - Pasqualone, Gianmario AU - Cimino, Carolina AU - Meddi, Elisa AU - Laureana, Roberta AU - Trivigno, Donata AU - Del Poeta, Giovanni AU - Mauriello, Alessandro AU - Anemona, Lucia AU - Postorino, Massimiliano AU - Cantonetti, Maria PY - 2022/01/01 Y2 - 2024/03/29 TI - Coexistence of T-Large Granular Lymphocyte Leukemia and Peripheral T Cell Lymphoma-NOS with indolent behaviour JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 14 IS - 1 SE - Case Reports DO - 10.4084/MJHID.2022.006 UR - https://www.mjhid.org/mjhid/article/view/4753 SP - e2022006 AB - <p>T-cell lymphomas and leukemias are highly heterogeneous groups of rare disorders. We report a case of a 68-year-old man patient who develops two different T-cell neoplasms (Large Granular Lymphocyte Leukemia [LGLL] in 2018 and Peripheral T-cell non-Hodgkin lymphoma&nbsp; not otherwise specified [PTCL-NOS] in 2019) with a previous diagnosis of B-cell marginal zone lymphoma in 2010, treated with two lines of chemo-immunotherapy. The coexistence of these different T-cell neoplasms is rarely reported in literature and, moreover, is usually described as an LGLL transformation into PTCL-NOS; differently from these examples, herein the simultaneous conditions appear to be driven by different T-cell clones. Furthermore, the PTCL-NOS had a quite unusual behaviour, with a good disease control without intensive treatment. Because of these features, it could belong to a subgroup of indolent PTCL-NOS, not yet described in the WHO classification of T-cell neoplasms, which could benefit of less aggressive treatment.</p> ER -