SERUM TOTAL BILIRUBIN, NOT CHOLELITHIASIS, IS INFLUENCED BY UGT1A1 POLYMORPHISM, ALPHA THALASSEMIA AND ?S GENOTYPE: FIRST REPORT ON COMPARISON BETWEEN ARAB-INDIAN AND AFRICAN ?S GENES

Abstract

Background: We explored the potential relationship between steady state serum bilirubin levels and the incidence of cholelithiasis in the context of UGT1A1 gene A(TA)nTAA promoter polymorphism in Omani sickle cell anemia (SCA) patients, homozygotes for African (Benin and Bantu) and Arab-Indian b^S haplotypes, but sharing the same microgeographical environment and comparable life style factors.

Methods: 136 SCA patients were retrospectively studied in whom imaging data including abdominal CT scan, MRI or Ultrasonography was routinely available. Available data on the mean steady state hematological/biochemical parameters (n=136),  b^s haplotypes(n=136), a globin gene status (n=105) and UGT1A1 genotypes(n=133) were reviewed from the respective medical records.

Results: The mean serum total bilirubin level was significantly higher in the homozygous UGT1A1(AT)₇ group as compared to  UGT1A1(AT)₆ group. Strikingly, cholelithiasis was not influenced by age, gender, alpha globin genotype or b^S haplotypes in this SCA cohort.

Conclusion: As observed in other population groups, the UGT1A1 (AT)₇ homozygosity was significantly associated with raised serum total bilirubin level, but the prevalence of gallstones in the Omani SCA patients was not associated with a thalassaemia, UGT1A1 polymorphism, or b^s haplotypes.