The diagnostic pitfalls of mucormycosis

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Margherita Mauro
a:1:{s:5:"en_US";s:114:"Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria integrata, Verona";}

Giuliana Lo Cascio
Unità Operativa Complessa di Microbiologia e virologia, Dipartimento di Patologia e diagnostica, Azienda Ospedaliera Universitaria Integrata, Verona, Italy

Rita Balter
Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria integrata, Verona , Italy

Ada Zaccaron
Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria integrata, Verona , Italy

Elisa Bonetti
Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria integrata, Verona , Italy

Virgina Vitale
Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria integrata, Verona, Italy

Matteo Chinello
1Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria integrata, Verona, Italy

Massimiliano De Bortoli
1Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria integrata, Verona, Italy

Paolo Brazzarola
Endocrine Surgery Unit, Department of Surgery and Oncology, University and Hospital Trust of Verona, Verona, Italy

Costanza Bruno
Department of Radiology, Radiology Institute, Verona, Italy

Simone Cesaro
Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria integrata, Verona , Italy

Keywords

pediatric non Hodgkin lymphoma, fungal infection, mucormycosis

Abstract

 


Background Invasive mucormycosis is a very aggressive fungal disease among immunocompromised pediatric patients caused by saprophytic fungi that belong to the order of the Mucorales.


Case Report We describe a case of  of Lichtheimia corymbifera infection in a 15-year-old child with B-cell Non-Hodgkin Lymphoma (NHL) involving lung, kidney and thyroid that initially was diagnosed as probable aspergillosis delaying the effective therapy for mucormycosis.


Conclusions This case showed that also intensive chemotherapy with rituximab may represent a risk factor for mucormycosis infection. Liposomal amphotericin B and surgery  remain  key tools  for a successful treatment of this aggressive disease. 

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Published
Oct 27, 2020
DOI https://doi.org/10.4084/mjhid.2020.079

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How to Cite

Mauro, M. (2020) “The diagnostic pitfalls of mucormycosis ”, Mediterranean Journal of Hematology and Infectious Diseases, 12(1), p. e2020079. doi: 10.4084/mjhid.2020.079.
Issue
Vol. 12 No. 1 (2020): Mediterranean Journal of Hematology and Infectious Diseases, Volume 12, 2020
Section
Case Reports
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