The venetoclax/azacitidine combination targets the disease clone in Acute Myeloid Leukemia, being effective and safe in a patient with COVID VEN/AZA effectively targets AML clones

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Antonio Cristiano
a:1:{s:5:"en_US";s:91:"Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome, Italy";}

Raffaele Palmieri
Emiliano Fabiani
Tiziana Ottone
Mariadomenica Divona
Arianna Savi
Francesco Buccisano
Luca Maurillo
Corrado Tarella
William Arcese
Maria Teresa Voso

Keywords

Venetoclax, venetoclax/azacitidine combination, AML, t-CMML, targeted-NGS

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References

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5. Rahmani NE, Ramachandra N, Sahu S, Gitego N, Lopez A, Pradhan K, et al. ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine. Blood Cancer J. 2021;11(9):157. https://doi.org/10.1038/s41408-021-00541-0
6. Cherry EM, Abbott D, Amaya M, McMahon C, Schwartz M, Rosser J, et al. Venetoclax and azacitidine compared with induction chemotherapy for newly diagnosed patients with acute myeloid leukemia. Blood Adv. 2021;5(24):5565-5573. https://doi.org/10.1182/bloodadvances.2021005538
7. DiNardo CD, Tiong IS, Quaglieri A, MacRaild S, Loghavi S, Brown FC, et al. Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML. Blood. 2020;135(11):791-803. https://doi.org/10.1182/blood.2019003988
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Published
Apr 28, 2022
DOI https://doi.org/10.4084/MJHID.2022.041

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How to Cite

Cristiano, A. (2022) “The venetoclax/azacitidine combination targets the disease clone in Acute Myeloid Leukemia, being effective and safe in a patient with COVID : VEN/AZA effectively targets AML clones”, Mediterranean Journal of Hematology and Infectious Diseases, 14(1), p. e2022041. doi: 10.4084/MJHID.2022.041.
Issue
Vol. 14 No. 1 (2022): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor
Section
Case Reports
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