Acquired Sideroblastic Anemia: An exploratory Comparative Statistical Analysis Between Clonal and Non-clonal cases Acquired Sideroblastic Anemia
Main Article Content
Keywords
Key words: sideroblastic anemia, copper deficiency, non-clonal sideroblastic anemia
Abstract
Sideroblastic anemia (SA) is a rare heterogenous group of inherited and acquired bone marrow disorders. We retrospectively studied the clinicopathologic characteristics, cytogenetic findings, and disease outcome of patients with acquired sideroblastic anemia (ASA) and performed a comparative analysis between clonal and non-clonal cases. 15 patients of ASA were detected: clonal SA (10 cases, 66.7%) including MDS, MDS/MPN, AML and t-MNs with ring sideroblasts) and SA secondary to non-clonal causes (5 cases; 33.3%), including copper deficiency (2 sideroblastic anemia, copper deficiency, non-clonal sideroblastic anemia cases), pyridoxine deficiency diagnosed during pregnancy, and 2 patients with idiopathic SA.Key
Keywords: sideroblastic anemia, copper deficiency, non-clonal sideroblastic anemia
Downloads
Abstract 421
PDF Downloads 338
HTML Downloads 149
References
2. Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405.
3. Mufti GJ, Bennett JM, Goasguen J, Bain BJ, Baumann I, Brunning R, et al. Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts. Haematologica. 2008;93(11):1712-7.
4. Brissot P, Bernard DG, Brissot E, Loréal O, Troadec MB. Rare anemias due to genetic iron metabolism defects. Mutat Res Rev Mutat Res. 2018 Jul - Sep; 777:52-63.
5. Papaemmanuil E, Gazzola M, Boultwood J, et al. (2011). Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 365:1 384- 95. PMID:21995386
6. Abu-Zeinah G, DeSancho MT. Understanding Sideroblastic Anemia: An Overview of Genetics, Epidemiology, Pathophysiology and Current Therapeutic Options. J Blood Med. 2020 Sep 25;11:305-318.
7. Alcindor T, Bridges KR (2002). Sideroblastic anaemias. Br J Haematol. 116:733-43. PMID:11886376
8. Ohba R, Furuyama K, Yoshida K, et al. Clinical and genetic characteristics of congenital sideroblastic anemia: comparison with myelodysplastic syndrome with ring sideroblast (MDS-RS). Ann Hematol. 2013. 92:1-9. PMID:22983749
9. Wazir SM, Ghobrial I. Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy. J Community Hosp Intern Med Perspect. 2017;7:265–8.
10. López Melero E, Ruíz-Roso G, Botella I, Ortego Pérez S, Delgado M, Fernández Lucas M. Pancytopenia due to copper deficiency in a hemodialysis patient. Nefrología.
11. Marumo A, Yamamura T, Mizuki T, Tanosaki S, Suzuki K. Copper deficiency induced pancytopenia after taking an excessive amount of zinc formulation during maintenance hemodialysis. J Res Med Sci 2021;26:42.2019;39:451–452.
12. Konopka L, Hoffbrand AV. Haem synthesis in sideroblastic anaemia. Br J Haematol. 1979;42(1):73–83. doi:10.1111/j.1365-2141.1979. tb 03699.x
13. Fei Wang, Geng Wang; Transient appearance of ring sideroblasts in peripheral blood in the acute phase of secondary hemolytic anemia. Blood 2019; 133 (9): 1000. Doi
14. Martin-Cabrera P, Jeromin S, Perglerovà K, Haferlach C, Kern W, Haferlach T. Acute myeloid leukemias with ring sideroblasts show a unique molecular signature straddling secondary acute myeloid leukemia and de novo acute myeloid leukemia. Haematologica. 2017;102(4):e125-e128. doi:10.3324/haematol.2016.156844
15. Kohla S, Ali E, Amer A, Yousif T, Yassin MA. A Rare Case of Severe Copper Deficiency in an Infant with Exclusive Breast Feeding Mimicking Myelodysplastic Syndrome. Case Rep Oncol. 2020 Feb 4;13(1):62-68. doi: 10.1159/000505483.
16. Shehab Fareed, Firyal Ibrahim, Mohamad Najib Alasafar, et al. Recurrent sideroblastic anaemia during pregnancy. Authorea. May 09, 2022 [ preprint].
Article Sidebar
Article Details
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers. Authors will grant copyright of their articles to the Institute of Hematology, Catholic University, Rome . No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.