A case of fatal hyperammonaemic encephalopathy in a patient with end-stage Multiple Myeloma treated with daratumumab

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Mauro Passucci
a:1:{s:5:"en_US";s:28:"La Sapienza University, Rome";}

Francesca Fazio
Department of Translational and Precision Medicine, La Sapienza University of Rome

Maria Teresa Petrucci
Department of Translational and Precision Medicine, La Sapienza University of Rome

Keywords

High risk Multiple Myeloma, hyperammonemia

Abstract

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References

1) Costa, L. J., & Usmani, S. Z. (2020). Defining and Managing High-Risk Multiple Myeloma: Current Concepts, Journal of the National Comprehensive Cancer Network J Natl Compr Canc Netw, 18(12), 1730-1737. Retrieved May 20, 2022, from https://jnccn.org/view/journals/jnccn/18/12/article-p1730.xml
2) Ikewaki J, Ogata M, Imamura T, Kohno K, Nakayama T, Kadota J. Development of hyperammonemic encephalopathy in patients with multiple myeloma may be associated with the appearance of peripheral blood myeloma cells. Leuk Lymphoma. 2009 Apr;50(4):667-9. doi: 10.1080/10428190902741489. PMID: 19373670.
3) Jaime Lora-Tamayo, Xavier Palom, José Sarrá, Oriol Gasch, Virginia Isern, Alberto Fernández de Sevilla, Ramón Pujol, Multiple Myeloma and Hyperammonemic Encephalopathy: Review of 27 Cases, Clinical Lymphoma and Myeloma, Volume 8, Issue 6, 2008, Pages 363-369, ISSN 1557-9190, https://doi.org/10.3816/CLM.2008.n.054.
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5) Howman R , Th akerer A , Pitman M , et al . Bortezomib, cyclophosphamide, and dexamethasone: highly eff ective for rapid reversal of myeloma-associated hyperammonemic encephalopathy . Leuk Lymphoma 2010 ; 51 : 2299 – 2302.
6) Amit Patel, Umeer Waheed, Stephen J. Brett, Amin Rahemtulla, Jane F. Apperley & Parind B. Patel (2014) Rapid initial response of myeloma hyperammonemic encephalopathy to L-ornithine-L-aspartate and dexamethasone therapy, Leukemia & Lymphoma, 55:1, 198-200
7) Anthony Pham, John L. Reagan, Jorge J Castillo; Plasma Cell Myeloma Causing Hyperammonemia Associated with High Inpatient Mortality. Blood 2012; 120 (21): 5002. doi: https://doi.org/10.1182/blood.V120.21.5002.5002
8) Murtaza G, Lu H, Faqah A, Konowitz N, Kuruvilla A, Adhikari S. Multiple Myeloma-Induced Hyperammonemic Encephalopathy. J Hematol. 2017;6(1):29-31. doi:10.14740/jh322e

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Published
Jan 1, 2023
DOI https://doi.org/10.4084/MJHID.2023.012

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How to Cite

Passucci, M., Fazio, F. and Petrucci, M. T. (2023) “A case of fatal hyperammonaemic encephalopathy in a patient with end-stage Multiple Myeloma treated with daratumumab”, Mediterranean Journal of Hematology and Infectious Diseases, 15(1), p. e2023012. doi: 10.4084/MJHID.2023.012.
Issue
Vol. 15 No. 1 (2023): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor
Section
Letters to the Editor
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