A rare case of multidrug resistant Leclercia adecarboxylata catheter-related bloodstream infection and an updated brief literature review Leclercia adecarboxylata catheter-related bloodstream infection.

Main Article Content

Cosimo Colangelo
Department of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia-ASST Spedali Civili, Brescia, Italy

Giorgio Tiecco
Department of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia-ASST Spedali Civili, Brescia, Italy

Marco Di Gregorio
Department of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia-ASST Spedali Civili, Brescia, Italy

Susanna Capone
Unit of Infectious and Tropical Diseases, ASST Spedali Civili, Brescia, Italy

Roberto Luigi Allegri
Unit of Infectious and Tropical Diseases, ASST Spedali Civili, Brescia, Italy

Maria De Francesco
Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 25123, Brescia, Italy.

Francesca Caccuri
Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 25123, Brescia, Italy.

Arnaldo Caruso
Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 25123, Brescia, Italy.

Francesco Castelli
Department of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia-ASST Spedali Civili, Brescia, Italy

Emanuele Focà
Università di Brescia

Keywords

Leclercia, Leclercia, adecarboxylata, MDR, CRBSI, CATHETER RELATED BLOODSTREAM INFECTION

Abstract

Leclercia adecarboxylata is a gram-negative bacillus, a ubiquitous microorganism, which may be found in both aquatic environments and soil, it was first described by H. Leclerc in 1962 and was reclassified thanks to more sensitive testing methods. L. adecarboxylata has been recently recognized as an emerging pathogen that causes several clinical syndromes not only in immunocompromised patients. 

Downloads

Download data is not yet available.


Abstract 396
PDF Downloads 361
HTML Downloads 89

References

1. Malik K, Davie R, Withers A, Faisal M, Lawal F. A case of Leclercia adecarboxylata endocarditis in a 62-year-old man. IDCases. 2021 Mar 27;24: e01091. doi: 10.1016/j.idcr. 2021.e01091. PMID: 33889491; PMCID: PMC8047457.
2. Zayet S, Lang S, Garnier P, Pierron A, Plantin J, Toko L, Royer PY, Villemain M, Klopfenstein T, Gendrin V. Leclercia adecarboxylata as Emerging Pathogen in Human Infections: Clinical Features and Antimicrobial Susceptibility Testing. Pathogens. 2021 Oct 28;10(11):1399. doi: 10.3390/pathogens10111399. PMID: 34832555; PMCID: PMC8619052.
3. Anuradha M. Leclercia adecarboxylata isolation: case reports and review. J Clin Diagn Res. 2014 Dec;8(12):DD03-4. doi: 10.7860/JCDR/2014/9763.5260. Epub 2014 Dec 5. PMID: 25653951; PMCID: PMC4316257.
4. Spiegelhauer MR, Andersen PF, Frandsen TH, Nordestgaard RLM, Andersen LP. Leclercia adecarboxylata: a case report and literature review of 74 cases demonstrating its pathogenicity in immunocompromised patients. Infect Dis (Lond). 2019 Mar;51(3):179-188. doi: 10.1080/23744235.2018.1536830. Epub 2018 Nov 29. PMID: 30488747.
5. Alosaimi RS, Muhmmed Kaaki M. Catheter-Related ESBL-Producing Leclercia adecarboxylata Septicemia in Hemodialysis Patient: An Emerging Pathogen? Case Rep Infect Dis. 2020 Jan 21;2020:7403152. doi: 10.1155/2020/7403152. PMID: 32089912; PMCID: PMC6996699.
6. Broderick A, Lowe E, Xiao A, Ross R, Miller R. Leclercia adecarboxylata folliculitis in a healthy swimmer-An emerging aquatic pathogen? JAAD Case Rep. 2019 Aug 5;5(8):706-708. doi: 10.1016/j.jdcr.2019.06.007. PMID: 31440563; PMCID: PMC6698442.
7. De Mauri A, Chiarinotti D, Andreoni S, Molinari GL, Conti N, De Leo M. Leclercia adecarboxylata and catheter-related bacteraemia: review of the literature and outcome with regard to catheters and patients. J Med Microbiol. 2013 Oct;62(Pt 10):1620-1623. doi: 10.1099/jmm.0.059535-0. Epub 2013 Jul 23. PMID: 23882033.
8. Shaikhain T, Al-Husayni F, Al-Fawaz S, Alghamdi EM, Al-Amri A, Alfares M. Leclercia adecarboxylata Bacteremia without a Focus in a Non-Immunosuppressed Patient. Am J Case Rep. 2021 Mar 30;22:e929537. doi: 10.12659/AJCR.929537. PMID: 33782375; PMCID: PMC8019838.
9. Bali R, Sharma P, Gupta K, Nagrath S. Pharyngeal and peritonsillar abscess due to Leclercia adecarboxylata in an immunocompetant patient. J Infect Dev Ctries. 2013 Jan 15;7(1):46-50. doi: 10.3855/jidc.2651. PMID: 23324820.
10. Shin GW, You MJ, Lee HS, Lee CS. Catheter-related bacteremia caused by multidrug-resistant Leclercia adecarboxylata in a patient with breast cancer. J Clin Microbiol. 2012 Sep;50(9):3129-32. doi: 10.1128/JCM.00948-12. Epub 2012 Jul 3. PMID: 22760051; PMCID: PMC3421816.
11. Gajdács, M.; Ábrók, M.; Lázár, A.; Terhes, G.; Burián, K. Leclercia adecarboxylata as an emerging pathogen in human infections: A 13-year retrospective analysis in Southern Hungary. J. Infect. Dev. Ctries. 2020, 14, 1004–1010.
12. Stock I, Burak S, Wiedemann B. 2004. Natural antimicrobial susceptibility patterns and biochemical profiles of Leclercia adecarboxylata strains. Clin. Microbiol. Infect. 10:724 –733.
13. Garza-González E, Bocanegra-Ibarias P, Rodríguez-Noriega E, González-Díaz E, SilvaSanchez J, Garza-Ramos U, Contreras-Coronado-Tovar IF, Santos-Hernández JE, Gutiérrez Bañuelos D, Mena-Ramirez JP, Ramírez-De-Los-Santos S, Camacho-Ortiz A, Morfín-Otero R. Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata. BMC Infect Dis. 2021 Feb 28;21(1):235. doi: 10.1186/s12879-021-05923-0. PMID: 33639886; PMCID: PMC7916303.
14. Hess B, Burchett A, Huntington MK. Leclercia adecarboxylata in an immunocompetent patient. J Med Microbiol. 2008 Jul;57(Pt 7):896-898. doi: 10.1099/jmm.0.47673-0. PMID: 18566150.
15. Hurley EH, Cohen E, Katarincic JA, Ohnmacht RK. Leclercia Adecarboxylata Infection in an Immunocompetent Child. R I Med J (2013). 2015 Sep 1;98(9):41-4. PMID: 26324975.
16. A. Mazzariol, J. Zuliani, R. Fontana, and G. Cornaglia, “Isolation from blood culture of a Leclercia adecarboxylata strain producing an SHV-12 extended-spectrum beta-lactamase,” Journal of Clinical Microbiology, vol. 41, no. 4, pp. 1738-1739, 2003.
17. Lee, B.; Sir, J.-J.; Park, S.-W.; Kwak, C.-H.; Kim, S.-M.; Kim, S.-B.; Cho, W.H.; Choi, S.-K.; Kwak, Y.G.; Whang, D.H. A Case of Leclercia adecarboxylata Endocarditis in a Woman with Endometrial Cancer. Am. J. Med. Sci. 2009, 337, 146–147.
18. Li, J.; Park, A.; Fulmer, B.R.; Garg, T. Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria. Urol. Case Rep. 2021, 36, 101579.
19. Ravikumar, R.; Patra, N.; Indiradevi, B. Prakash Hospital-acquired pneumonia due to Leclercia adecarboxylata in a neurosurgical centre. J. Postgrad. Med. 2015, 61, 123–125.
20. Hassan, I.; Gupta, P.; Ray, P.; Tiewsoh, K. Leclercia adecarboxylata Causing Spontaneous Bacterial Peritonitis in a Child with Nephrotic Syndrome: A Case Report and Review of Literature. J. Lab. Physicians 2020, 12, 222–224.
21. Adapa, S.; Konala, V.M.; Nawaz, F.; Javed, T.; Dhingra, H.; Gutierrez, I.A.; Ramirez, M.L. Peritonitis from Leclercia adecarboxylata: An emerging pathogen. Clin. Case Rep. 2019, 7, 829–831.
22. Riazzo C, López-Cerero L, Rojo-Martín MD, Hoyos-Mallecot Y, Fernández-Cuenca F, Martín-Ruíz JL, Pascual-Hernández Á, Naas T, Navarro-Marí JM. First report of NDM-1-producing clinical isolate of Leclercia adecarboxylata in Spain. Diagn Microbiol Infect Dis. 2017 Jul;88(3):268-270. doi: 10.1016/j.diagmicrobio.2017.04.013. Epub 2017 May 3. PMID: 28506721.

Article Sidebar

PDF HTML
Published
Aug 29, 2023
DOI https://doi.org/10.4084/MJHID.2023.052

Article Details

How to Cite

Colangelo, C. (2023) “A rare case of multidrug resistant Leclercia adecarboxylata catheter-related bloodstream infection and an updated brief literature review: Leclercia adecarboxylata catheter-related bloodstream infection”., Mediterranean Journal of Hematology and Infectious Diseases, 15(1), p. e2023052. doi: 10.4084/MJHID.2023.052.
Issue
Vol. 15 No. 1 (2023): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor
Section
Letters to the Editor
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Transfer of Copyright and Permission to Reproduce Parts of Published Papers. Authors will grant copyright of their articles to the Institute of Hematology, Catholic University, Rome . No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.