CAUSAL RELATIONSHIP BETWEEN HELICOBACTER PYLORI ANTIBODIES AND IMMUNE THROMBOCYTOPENIA: A MENDELIAN RANDOMIZATION STUDY

Abstract

Background

Previous observational studies have suggested a potential causal relationship between Helicobacter pylori (H. pylori) infection and Immune thrombocytopenia (ITP). However, the evidence for causal inference remains contentious, and the underlying mechanisms require further investigation. In order to delve deeper into the relationship between H. pylori and ITP, we conducted a Mendelian randomization (MR) analysis.

Method

In this study, we used two-sample Mendelian Randomization (MR) to assess the causality of seven different specific protein antibodies targeting H. pylori on ITP. 76 single nucleotide polymorphisms (SNPs) related to H. pylori antibodies levels were obtained from the European Bioinformatics Institute (EBI). Summary data of ITP was obtained from the FinnGen database, Inverse variance weighted (IVW) analysis was identified as our main method. To ensure the reliability of the findings, many sensitivity analyses were performed.

Result

Genetically predicted serum levels of H. pylori GroEL antibodies were positively associated with an increased risk of ITP (odds ratio [OR] = 1.802, 95% CI 1.106–2.936, P = 0.01799). No causal relationship was found between other H. pylori antibodies and ITP.

Conclusion

The outcomes derived from our two-sample Mendelian randomization analysis demonstrate a discernible link between the levels of H. pylori GroEL antibodies and an augmented susceptibility to ITP. However, it is imperative to expand the sample size further in order to corroborate the correlation between H. pylori infection and ITP.